468065-27-2

Upstream product

• 100-39-0 benzyl bromide 
• 468065-22-7 O-3-azido-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diazido-2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→4)]-1,3-diazido-1,2,3-trideoxy-D-myo-inositol 
• 32986-56-4 tobramycin 

Downstream Products

• 844837-51-0 (2R,3S,4S,5R,6R)-4-Azido-3,5-bis-benzyloxy-2-benzyloxymethyl-6-p-tolylsulfanyl-tetrahydro-pyran 
• 738602-11-4 (2R,3R,4S,5S,6S)-3,4,5-Tris-benzyloxy-2-benzyloxymethyl-6-[(1S,2S,3R,4S,6R)-4,6-diazido-3-((2R,3R,5S,6R)-3-azido-6-azidomethyl-5-benzyloxy-tetrahydro-pyran-2-yloxy)-2-benzyloxy-cyclohexyloxy]-tetrahydro-pyran 
• 738602-00-1 (2S,3R,4S,5R,6S)-3-Azido-4,5-bis-benzyloxy-2-benzyloxymethyl-6-[(1S,2S,3R,4S,6R)-4,6-diazido-3-((2R,3R,5S,6R)-3-azido-6-azidomethyl-5-benzyloxy-tetrahydro-pyran-2-yloxy)-2-benzyloxy-cyclohexyloxy]-tetrahydro-pyran 
• 738602-01-2 (2R,3R,4S,5R,6R)-2-Azidomethyl-3,4,5-tris-benzyloxy-6-[(1S,2S,3R,4S,6R)-4,6-diazido-3-((2R,3R,5S,6R)-3-azido-6-azidomethyl-5-benzyloxy-tetrahydro-pyran-2-yloxy)-2-benzyloxy-cyclohexyloxy]-tetrahydro-pyran 
• 738602-12-5 (2S,3S,4R,5S,6R)-3-Azido-4,5-bis-benzyloxy-6-benzyloxymethyl-2-[(1S,2S,3R,4S,6R)-4,6-diazido-3-((2R,3R,5S,6R)-3-azido-6-azidomethyl-5-benzyloxy-tetrahydro-pyran-2-yloxy)-2-benzyloxy-cyclohexyloxy]-tetrahydro-pyran 
• 738602-18-1 (2S,3S,4R,5R,6S)-3,4,5-Tris-benzyloxy-2-[(1S,2S,3R,4S,6R)-4,6-diazido-3-((2R,3R,5S,6R)-3-azido-6-azidomethyl-5-benzyloxy-tetrahydro-pyran-2-yloxy)-2-benzyloxy-cyclohexyloxy]-6-methyl-tetrahydro-pyran 
• 738602-06-7 (2S,3S,4S,5R,6R)-3,4-Diazido-5-benzyloxy-2-benzyloxymethyl-6-[(1S,2S,3R,4S,6R)-4,6-diazido-3-((2R,3R,5S,6R)-3-azido-6-azidomethyl-5-benzyloxy-tetrahydro-pyran-2-yloxy)-2-benzyloxy-cyclohexyloxy]-tetrahydro-pyran 
• 738602-07-8 (2S,3S,4S,5R,6S)-3,4-Diazido-5-benzyloxy-2-benzyloxymethyl-6-[(1S,2S,3R,4S,6R)-4,6-diazido-3-((2R,3R,5S,6R)-3-azido-6-azidomethyl-5-benzyloxy-tetrahydro-pyran-2-yloxy)-2-benzyloxy-cyclohexyloxy]-tetrahydro-pyran 

Relevant academic research and scientific papers

Tobramycin and nebramine as pseudo-oligosaccharide scaffolds for the development of antimicrobial cationic amphiphiles

Antimicrobial cationic amphiphiles derived from aminoglycoside pseudo-oligosaccharide antibiotics interfere with the structure and function of bacterial membranes and offer a promising direction for the development of novel antibiotics. Herein, we report

Aminoglycoside antibiotics as novel anti-infective agents

This invention relates to novel aminoglycoside compounds having antibacterial and anti-infective activity and to pharmaceutical compositions, methods of making and methods of treatment employing the same.

Glyco-optimization of aminoglycosides: New aminoglycosides as novel anti-infective agents

Glyco-optimization (OPopSTM) of aminoglycosides has been performed by replacing the existing sugar moiety with a variety of sugar derivatives. Glycosylation of the 6-position of nebramine provided a library of novel 4,6-linked aminoglycosides (

Targeting RNAs with tobramycin analogues

(Chemical equation presented). A library of 4,6-linked analogues of the drug tobramycin with various mono- or diaminosugars attached to the 6-position of the two-ring core has been prepared (see scheme; Bn = benzyl, Tol = p-tolyl). The compounds were scre