46852-30-6

Upstream product

• 50673-01-3 benzoic acid-(2-hydroxy-2-phenyl-propylamide) 
• 103738-73-4 N-<1-(methylthio)benzylidene>-1-(trimethylsilyl)methylamine 
• 98-86-2 acetophenone 
• 88122-92-3 1-benzamido-1-phenylpropan-2-ol 
• 98-88-4 benzoyl chloride 
• 582-61-6 benzoyl azide 
• 98-83-9 isopropenylbenzene 
• 1390632-64-0 N-(2-phenylpropyl)benzimidamide 
• 582-22-9 2-phenylpropylamine 
• 3360-52-9 3-chloro-2-phenylprop-1-ene 
• 100-58-3 phenylmagnesium bromide 
• 120869-19-4 2-phenylpropionaldimine 
• 34713-70-7 2-Phenylpropanal 
• 582-22-9 (R)-2-phenylpropylamine 

Downstream Products

• 88122-94-5 4-methyl-1-phenylisoquinoline 

Relevant academic research and scientific papers

Visible Light-Induced Regioselective Cycloaddition of Benzoyl Azides and Alkenes to Yield Oxazolines

Visible light catalysis allows the regioselective synthesis of oxazolines in high yields. The mild photosensitized manifold leverages the intermolecular formation of oxazolines with a wide functional group tolerance on both benzoyl azides and alkenes part

Copper-catalyzed aerobic aliphatic C-H oxygenation directed by an amidine moiety

A method for the oxygenation of tertiary C-H bonds of N-alkylamidines and N-(2-alkylaryl)amidines is described that utilizes the CuBr?SMe 2/2,2′-bipyridine catalytic system under an O2 atmosphere and provides dihydrooxazoles and 4H-1,3-benzoxazines. The oxygen atom is incorporated from atmospheric molecular oxygen during the present process.

Asymmetric N1 unit transfer to olefins with a chiral nitridomanganese complex: Novel stereoselective pathways to aziridines or oxazolines

Chiral nitridomanganese complex 1 was found to be a highly potential N1 unit source for the asymmetric synthesis of aziridines and 2-oxazolines from olefins such as styrene and its derivatives. When sulfonyl chlorides were employed as activators of the complex in the presence of pyridine, pyridine N-oxide, and a silver salt, the reaction of olefins with complex 1 proceeded smoothly to afford the N-sulfonylated aziridines. The aziridination of styrene derivatives with complex 1 using 2-trimethylsilylethanesulfonyl chloride (SESC1) gave the N-SES-aziridines, which were easily converted into chiral N-unsubstituted aziridines. It was found that the reaction was applicable to the asymmetric synthesis of 2-oxazolines from olefins when acyl chlorides were employed as activators. Complex I provided an effective asymmetric environment for trans-disubstituted styrenes in the reaction (up to 92% ee). This is the first example of a direct asymmetric synthesis of 2-oxazolines from olefins. Additional experiments, conducted during the course of this investigation, suggest that the isomerization of the N-acylaziridine intermediate is involved in this reaction.

Regioselective Cycloadditions of N-Protonated Azomethine Ylides and 2-Azaallyl Anions Generated from N-(Silylmethyl) Thioimidates, Synthetic Equivalents of Nonstabilized Nitrile Ylides

A water-induced-desilylation method and a direct-desilylation method have been applied to N-(silylmethyl) thioimidates to lead to the generation of N-protonated azomethine ylides and 2-azaallyl anions, respectively.These reactive intermediates are capture

ISOQUINOLINE SYNTHESES VIA 2-OXAZOLINES. PART V. SYNTHESES OF 4-ALKYL-1-PHENYLISOQUINOLINES BY PICTET-GAMS REACTION

Conditions necessary for transformation of hydroxyamides (4) and 2-oxazolines (5) into 4-alkyl-1-phenylisoquinolines have been established.The mechanism of the Pictet-Gams reaction claiming the existence of protonated oxazolines (7) and unsaturated amides