Welcome to LookChem.com Sign In|Join Free


  • or


Post Buying Request

4695-17-4 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

4695-17-4 Usage

Chemical class

Thiazolidinedione derivatives

Common use

Pharmaceutical intermediate in synthesizing drugs, especially for diabetes treatment


Anti-inflammatory: Studied for potential anti-inflammatory properties
Anti-diabetic: Studied for potential anti-diabetic properties
Metabolism modulation: Ability to modulate glucose and lipid metabolism

Therapeutic potential

Potential treatment for various inflammatory and metabolic disorders


Researchers and pharmaceutical companies are interested in its therapeutic applications

Check Digit Verification of cas no

The CAS Registry Mumber 4695-17-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,6,9 and 5 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 4695-17:
114 % 10 = 4
So 4695-17-4 is a valid CAS Registry Number.

4695-17-4Relevant articles and documents

Identification of a New Zinc Binding Chemotype by Fragment Screening

Chrysanthopoulos, Panagiotis K.,Mujumdar, Prashant,Woods, Lucy A.,Dolezal, Olan,Ren, Bin,Peat, Thomas S.,Poulsen, Sally-Ann

, p. 7333 - 7349 (2017/09/22)

The discovery of a new zinc binding chemotype from screening a nonbiased fragment library is reported. Using the orthogonal fragment screening methods of native state mass spectrometry and surface plasmon resonance a 3-unsubstituted 2,4-oxazolidinedione fragment was found to have low micromolar binding affinity to the zinc metalloenzyme carbonic anhydrase II (CA II). This affinity approached that of fragment sized primary benzenesulfonamides, the classical zinc binding group found in most CA II inhibitors. Protein X-ray crystallography established that 3-unsubstituted 2,4-oxazolidinediones bound to CA II via an interaction of the acidic ring nitrogen with the CA II active site zinc, as well as two hydrogen bonds between the oxazolidinedione ring oxygen and the CA II protein backbone. Furthermore, 3-unsubstituted 2,4-oxazolidinediones appear to be a viable starting point for the development of an alternative class of CA inhibitor, wherein the medicinal chemistry pedigree of primary sulfonamides has dominated for several decades.


Majcen Le Marechal,Robert,Leban

, p. 453 - 464 (2007/10/02)

The nucleophilic ring opening of gem dicyano epoxides by N-substituted or N-N′ disubstituted thioureas leads to 2-imino 4-thiazolidinones, via postulated cyanoformyl intermediates, compounds 7 can exist in tautomeric equilibrium with a tautomeric 2-amino 4-hydroxy thiazolines. However, the cyanoformyl intermediates evolve differently when dicyano epoxides are reacted with 2-thioxobenzoxazole, 2-(aryl cyanoformyl) methylene be.

Studies on antidiabetic agents. III. 5-arylthiazolidine-2,4-diones as potent aldose reductase inhibitors


, p. 3601 - 3616 (2007/10/02)


Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)


What can I do for you?
Get Best Price

Get Best Price for 4695-17-4