4695-21-0

Upstream product

• 600-00-0 ethyl 2-bromoisobutyrate 
• 103-85-5 monophenylthiourea 
• 1011291-12-5 5,5-dimethyl-2-(methylthio)thiazol-4(5H)-one 
• 62-53-3 aniline 
• 1011290-97-3 1-(2-(4-methoxybenzylthio)-2-methylpropanoyl)-2-methyl-3-phenylisothiourea 
• 54856-42-7 4-dimethylamino-5,5-dimethyl-2-phenylimino-3-(phenyl-thiocarbamoyl)-2,5-dihydro-thiazolium betaine 
• 67-66-3 chloroform 
• 67-64-1 acetone 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 93150-14-2 5,5-dimethyl-2-phenylimino-3-pyrrolidin-1-ylmethyl-thiazolidin-4-one 
• 93725-24-7 5,5-dimethyl-2-phenylimino-3-piperidin-1-ylmethyl-thiazolidin-4-one 
• 95705-08-1 5,5-dimethyl-3-phenothiazin-10-ylmethyl-2-phenylimino-thiazolidin-4-one 
• 93150-27-7 5,5-dimethyl-3-morpholin-4-ylmethyl-2-phenylimino-thiazolidin-4-one 

Relevant academic research and scientific papers

New methods for the synthesis of 2-aminothiazolones

(Chemical Equation Presented) Two new methods for the synthesis of 2-aminothiazolones from 2-(4-methoxybenzylthio)acetic acids are described. A single reagent and simple experimental conditions are used in the key tandem deprotection-cyclization process. In the first approach 2-aminothiazolones are directly accessed via cyclization of the corresponding N-acylisothioureas. The second complementary approach provides access to a variety of 2-thiomethylthiazolones via cyclization of N-acyldithioimidates. The product 2-thiomethylthiazolones are then efficiently converted to 2-aminothiazolones via amine displacement.