4696-96-2

Upstream product

• 2168-85-6 methyl phenyldithioacetate 
• 109-89-7 diethylamine 
• 98-86-2 acetophenone 
• 25445-77-6 4-phenyl-1,2,3-thiadiazole 
• 536-74-3 phenylacetylene 
• 83893-97-4 (thiocyanatoethynyl)benzene 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 121-44-8 triethylamine 
• 1483-82-5 phenylethynyl chloride 

Downstream Products

• 19429-45-9 1r-Diethylamino-2c-phenyl-2-ethyl-mercaptoethen 
• 34906-86-0 N,N-diethyl-2-oxo-2-phenylacetamide 
• 20761-89-1 N,N-Diaethyl-2-phenyl-thiopenten-⁽⁴⁾-saeureamid 
• 2431-96-1 N,N-diethylphenylacetamide 

Relevant academic research and scientific papers

Rapid and efficient protocol for Willgerodt–Kindler’s thioacetamides catalyzed by sulfated polyborate

Abstract: A simple and efficient method for the synthesis of one-pot, three-component thioacetamides via Willgerodt–Kindler reaction was developed using a sulfated polyborate catalyst. The method described the reaction of ketones, sulfur, and secondary am

Synthesis of thioamides via one-pot A3-coupling of alkynyl bromides, amines, and sodium sulfide

We herein describe a novel method for the synthesis of thioamides by a three component condensation of alkynyl bromides, amines, and Na 2S·9H2O. The developed method is applicable for a wide range of amines and alkynyl bromides bearing different functional groups furnishing the corresponding products in moderate to excellent yields. The Royal Society of Chemistry.

Optimum Conditions for the Willgerodt-Kindler Reaction. 3. Amine Variation

Optimum conditions for the synthesis of phenylacetic acid thioamids by the joint action of elemental sulfur and amines on acetophenons have been studied with the following amines: Morpholine, pyrrolidine, 4-methylpiperidine, isopropylamine, 2-butylamine,

Reactions of 1-alkynyl thiocyanates with nucleophilic reagents. Synthesis of 2,4-disubstituted 1,3-thiazoles

Reaction of 1-alkynyl thiocyanates RCC-S-CN (1) with alcohols, phenol or thiols or secondary aliphatic amines in the presence of anhydrous zinc chloride or boron trifluoride diethyl etherate gives mixtures of 2,4-disubstituted 1,3-thiazoles (2), thiocarbonyl compounds (3) (thiono esters, dithio esters or thioamides) and 2-alkylidene-1,3-dithioles (4).In all cases, the 1,3-thiazoles can be obtained in good yields if the proper reaction conditions are applied.Interaction between 1 and lithium dialkylamides LiNR'2 gives the compounds RCC-S-NR'2 (5) (attack on sulfur).With alkoxides R'O1-, the primary attack is on CN: the in termediacy alkynethiolate RCC-S1- subsequently reacts with the alkyl cyanate R'OCN to afford 1-alkynyl sulfides RCC-SR'(6)