Bifunctional antitumor agents. Derivatives of pyrrolo[9,10-b]phenanthrene - A DNA intercalative delivery template

Article abstract of DOI:10.1016/S0040-4020(97)00991-5

The preparation and intercalative ability of the pyrrolo[9,10-b]phenanthrene nucleus is described. Functionalization of the nucleus was achieved using standard indole chemistry. The utility of this template as a DNA intercalating drug delivery system is demonstrated by synthesis of a derived bis-chloroethylamine alkylating system and a hybrid DNA interactive enediyne system.