471-10-3

Basic information

• Product Name: 3-chloro-3,7-dimethylocta-1,6-diene
• Synonyms: 3-chloro-3,7-dimethylocta-1,6-diene;3-Chloro-3,7-dimethyl-1,6-octadiene
• CAS NO: 471-10-3
• Molecular Formula: C₁₀H₁₇Cl
• Molecular Weight: 172.69498
• EINECS: 207-435-7
• Mol File: 471-10-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 213.4°Cat760mmHg
• Flash Point: 80.3°C
• Appearance: /
• Density: 0.892g/cm³
• Vapor Pressure: 0.239mmHg at 25°C
• Refractive Index: 1.458
• CAS DataBase Reference: 3-chloro-3,7-dimethylocta-1,6-diene(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-3,7-dimethylocta-1,6-diene(471-10-3)
• EPA Substance Registry System: 3-chloro-3,7-dimethylocta-1,6-diene(471-10-3)

Safety Data

• Hazardous Substances Data: 471-10-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H17Cl/c1-5-10(4,11)8-6-7-9(2)3/h5,7H,1,6,8H2,2-4H3

Upstream product

• 4490-10-2 geranyl chloride 
• 503-60-6 3,3-dimethyl-allyl chloride 
• 78-79-5 isoprene 
• 106-24-1 Geraniol 
• 106-25-2 Nerol 
• 78-70-6 3,7-dimethylocta-1,6-dien-3-ol 
• 624-15-7 geraniol 
• 126-90-9 (S)-(+)-linalool 
• 7647-01-0 hydrogenchloride 
• 123-35-3 7-methyl-3-methene-1,6-octadiene 
• 67-66-3 chloroform 
• 7719-12-2 phosphorus trichloride 
• 563-52-0 2-chloro-3-butene 
• 2270-59-9 1-bromo-4-methylpent-3-ene 

Downstream Products

• 115-95-7 linalool acetate 
• 126-91-0 linalool 
• 18172-67-3 beta-pinene 
• 5392-40-5 (E/Z)-3,7-dimethyl-2,6-octadienal 
• 78-70-6 3,7-dimethylocta-1,6-dien-3-ol 

Relevant articles and documents

Formamide-Catalyzed Nucleophilic Substitutions: Mechanistic Insight and Rationalization of Catalytic Activity

Herein, detailed mechanistic investigations into formamide-catalyzed nucleophilic substitution (SN) of alcohols are reported. Alkoxyiminium chlorides and hexafluorophosphates were synthesized and characterized as a key intermediate of the catalytic cycle. The determination of reaction orders and control experiments indicated that the nucleophilic attack of the formamide catalyst onto the reagent BzCl is the rate-determining step. Linear free energy relationship revealed a correlation between the quantified Lewis basicity strength of formamides by means of 11B NMR spectroscopy and their catalytic activity in SN-transformations. The observed difference in catalytic ability was attributed to the natural bond order charge, dipole moment, and Sterimol parameter B5. Importantly, this rationalization enables the prediction of the capacity of formamides to promote SN-type transformations in general.

Systematic Evaluation of Sulfoxides as Catalysts in Nucleophilic Substitutions of Alcohols

Herein, a method for the nucleophilic substitution (SN) of benzyl alcohols yielding chloro alkanes is introduced that relies on aromatic sulfoxides as Lewis base catalysts (down to 1.5 mol-%) and benzoyl chloride (BzCl) as reagent. A systematic screening of various sulfoxides and other sulfinyl containing Lewis bases afforded (2-methoxyphenyl)methyl sulfoxide as optimal catalyst. In contrast to reported formamide catalysts, sulfoxides also enable the application of plain acetyl chloride (AcCl) as reagent. In addition, it was demonstrated that weakly electrophilic carboxylic acid chlorides like BzCl promote Pummerer rearrangement of sulfoxides already at room temperature. This side-reaction also provided the explanation, why sulfoxide catalyzed SN-reactions of alcohols do not allow the effective production of aliphatic and electron deficient chloro alkanes. Comparison experiments provided further insight into the reaction mechanism.

METHOD OF CONVERTING ALCOHOL TO HALIDE

The present invention relates to a method of converting an alcohol into a corresponding halide. This method comprises reacting the alcohol with an optionally substituted aromatic carboxylic acid halide in presence of an N-substituted formamide to replace a hydroxyl group of the alcohol by a halogen atom. The present invention also relates to a method of converting an alcohol into a corresponding substitution product. The second method comprises: (a) performing the method of the invention of converting an alcohol into the corresponding halide; and (b) reacting the corresponding halide with a nucleophile to convert the halide into the nucleophilic substitution product.