4714-69-6

Usage

InChI:InChI=1/C9H12N2S/c1-11(2)8-5-3-7(4-6-8)9(10)12/h3-6H,1-2H3,(H2,10,12)

Upstream product

• 1197-19-9 4-cyano-N,N-dimethylaniline 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 2929-84-2 4-dimethylaminobenzaldehyde oxime 
• 75-15-0 carbon disulfide 
• 7664-41-7 ammonia 
• 107-56-2 O,O-diisopropyl hydrogen phosphorodithioate 

Downstream Products

• 104851-95-8 N,N-dimethyl-4-(4-methyl-thiazol-2-yl)-aniline 
• 3816-95-3 2-(4-dimethylamino-phenyl)-thiazole-4,5-dione 
• 18046-20-3 [2-(4-dimethylamino-phenyl)-4-phenyl-thiazol-5-yl]-acetic acid 
• 115541-00-9 2-(4-N,N-dimethylaminophenyl)-4-(2'-pyrazinyl)thiazole 
• 88735-51-7 3-[2-(4-Dimethylamino-phenyl)-thiazol-4-yl]-chromen-2-one 
• 80784-76-5 C₁₇H₁₇N₃O₃S 
• 95642-50-5 2-p-(dimethylaminophenyl)-4-hydroxy-6H-1,3-thiazin-6-one 
• 123858-76-4 5-Benzoyl-2-(4-dimethylaminophenyl)-4-phenylthiazol 
• 123858-82-2 2-(Dimethylaminophenyl)-5-(4-methoxybenzoyl)-4-(4-methoxyphenyl)thiazol 
• 88735-55-1 2-[2-(4-Dimethylamino-phenyl)-thiazol-4-yl]-benzo[f]chromen-3-one 
• 88735-60-8 7-diethylamino-3-[2-(4-dimethylamino-phenyl)-thiazol-4-yl]-chromen-2-one 
• 70121-13-0 3,5-bis(4-(N,N-dimethylamino)phenyl)-1,2,4-thiadiazole 
• 123858-72-0 2-p-dimethylaminophenyl-5,6-diphenyl-4H-1,3-oxazin-4-one 
• 123858-73-1 5,6-Bis(4-chlorphenyl)-2-(4-dimethylaminophenyl)-4H-1,3-oxazin-4-on 

Relevant academic research and scientific papers

Mo (CO)6-assisted Pd-supported magnetic graphene oxide-catalyzed carbonylation-cyclization as an efficient way for the synthesis of 4(3H)-quinazolinones

In this paper, a novel catalyst is introduced based on the immobilization of palladium on modified magnetic graphene oxide nanoparticles. The catalyst is characterized by several methods, including transmission electron microscopy, scanning electron microscopy, X-ray fluorescence, vibrating-sample magnetometer, Fourier transform-infrared and dynamic light scattering (DLS) analysis. The activity of the catalyst was investigated in the synthesis of 4(3H)-quinazolinones via Pd-catalyzed carbonylation-cyclization of N-(2-bromoaryl) benzimidamides by Mo (CO)6. The Mo (CO)6 is used as a carbon monoxide source for performing the reaction under mild conditions. The catalyst showed good reusability, and no change in activity was observed after 10?cycles of recovery.

Photomodulation of the proton affinity and acid gated photochromism of a novel dimethylaminophenyl thiazole diarylethene

The acid-gated photochromism and the photomodulation of fluorescence and proton affinity of a novel dimethylaminophenyl thiazole diarylethene in MeCN were investigated from a kinetic point of view. Photomodulation of the proton affinities has been estimat

2-Aryl-4,5,6,7-tetrahydro-1,3-benzothiazol-7-ols as a class of antitumor agents selectively active in securin-/- cells

A series of 2-(4-aminophenyl)-4,5,6,7-tetrahydro-1,3-benzothiazol-7-ols have been developed as antitumor agents that showed high selectivity against aneuploid cell lines (vs diploid cell lines). Structure-activity relationship studies showed that a hydroxymethyl group at the 2-position of the phenyl ring increased potency and selectivity. A pyrrolidinyl group at the 4-position of the phenyl ring was comparable to a dimethylamino group. The corresponding 5-aza analogs, 2-(4-aminophenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[4,5-c]pyridin-7-ols, retained potency and high level of selectivity against aneuploid cell growth (vs diploid cells). These 5-aza compounds exhibited higher water solubility and higher metabolic stability than the corresponding carba analogs. Compound 19 showed the highest potency against MCF-7 and MDA-MB-361 lines and was selected for further evaluation.

One-step conversion of alcohols into thioesters

A one-step conversion of alcohols into thioesters under solvent-free conditions is reported. The alcohols were reacted with primary thioamides in the presence of p-toluenesulfonic acid under solvent-free conditions to produce the corresponding thioesters in good to excellent yields. Georg Thieme Verlag Stuttgart - New York.

2-ARYL- AND 2-HETEROARYLTHIAZOLYL COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF

The present invention discloses fused bicyclic 2-aryl- or 2-heteroarylthiazolyl compounds and their pharmaceutically acceptable salts and esters thereof, which are useful for inhibiting the growth of cancerous cells, inhibiting human breast carcinoma tumo

CONVERSION OF NITRILES TO THIOAMIDES UNDER THE ACTION OF THE BINARY THIONYLATING SYSTEM PHOSPHORUS DITHIOACID-ALCOHOL

Binary systems of phosphorus dithioacid-methanol and phosphorus pentasulfide-methanol are effective hydrosulfonating systems for the conversion of aromatic nitriles to the corresponding primary thioamides.In ternary systems nitrile-phosphorus dithioacid-alcohol from one to four parallel processes can occur.The structure of the phosphorus dithioacids has little effect, whereas the structures of the nitrile and alcohol substantially influence both the rate of the processes and the possible pathway.The reactivity of alcohols in these reactions drops with increasing volume of the hydrocarbon radical.

Synthesis and Antitubercular Activity of 4-(5-Nitro-2-furyl/2-pyrazinyl/1-adamantyl)-2-(alkyl/aryl/arylamino)thiazoles

The reaction of haloketones, obtained from Arndt-Eistert reaction on the acid chlorides of 1-adamantane, 5-nitrofuroic acid and pyrazine-2-carboxylic acid, with different thioamides and thioureas affords the title thiazoles (I-III).Some of them exhibit interesting antitubercular activity at 6.25 to 0.38 μg/ml concentration against H37Rv strain of M. tubercolosis in vitro testing.The structure activity relationship (SAR) has also been discussed.