471911-16-7

Basic information

• Product Name: 4-(4-Acetoxyphenyl)-2-aminothiazole, 97%
• Synonyms: 4-(4-Acetoxyphenyl)-2-aminothiazole, 97%
• CAS NO: 471911-16-7
• Molecular Formula: C11H10N2O2S
• Molecular Weight: 234.2743
• Mol File: 471911-16-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(4-Acetoxyphenyl)-2-aminothiazole, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Acetoxyphenyl)-2-aminothiazole, 97%(471911-16-7)
• EPA Substance Registry System: 4-(4-Acetoxyphenyl)-2-aminothiazole, 97%(471911-16-7)

Safety Data

• Hazardous Substances Data: 471911-16-7(Hazardous Substances Data)

Upstream product

• 57634-55-6 4-(2-aminothiazol-4-yl)phenol 
• 108-24-7 acetic anhydride 
• 41104-10-3 acetic acid 4-(2-bromoacetyl)phenyl ester 
• 62-56-6 thiourea 
• 2628-16-2 p-acetoxystyrene 

Relevant articles and documents

One-pot synthesis of 4-aryl-2-aminothiazoles from styrenes and thioureas promoted by tribromoisocyanuric acid

A simple and efficient one-pot protocol has been developed for the conversion of styrenes into 4-aryl-2-aminothiazoles using readily available starting materials. Tribromoisocyanuric acid was successfully used for the co-bromination and oxidation of styrenes to give phenacyl bromides, which in the presence of thioureas produced the corresponding 4-aryl-2-aminothiazoles in 48–70% yield. The protocol involves three reactions in one process: a tandem (formation of phenacyl bromides from styrenes) followed by a telescoped (conversion to thiazole) reaction.

Ac2O-Py/basic alumina as a versatile reagent for acetylations in solvent-free conditions under microwave irradiation

Acetic anhydride-pyridine over basic alumina has been used in order to carry out acetylations of hydroxy, thiol and amino groups in solvent-free conditions under microwave irradiation. The technique can be extended for selective acetylations by regulation of irradiation time.