4726-27-6Relevant academic research and scientific papers
Iodine/DMSO-Promoted Selective Direct Arylthiation of Anilines with Thiols under Metal-Free Conditions
Zhao, Wenqi,Zhang, Feng,Deng, Guo-Jun
, p. 291 - 301 (2021/01/14)
An iodine-promoted divergent thiolation of unprotected anilines with thiols for the synthesis of sulfide anilines has been described. The combinational use of I2 and DMSO played an important role to realize this kind of transformation without the aid of a
Flavin/I2 catalyzed aerobic oxidative C–H sulfenylation of anilines
Jiang, Xinpeng,Shen, Zhifeng,Zheng, Cong,Fang, Liyun,Chen, Keda,Yu, Chuanming
supporting information, (2020/07/24)
A flavin/I2 catalyzed aerobic oxidative C–H sulfenylation of anilines with thiols under mild reaction conditions is presented for the first time. This metal-free reaction provides an atom-economic pathway to prepare various aryl sulfides with outstanding functional group compatibility. Moreover, it consumes molecular oxygen as the only terminal oxidant and produces environmentally-friendly H2O as the only byproduct.
Structure-based design of substituted diphenyl sulfones and sulfoxides as lipophilic inhibitors of thymidylate synthase
Jones, Terence R.,Webber, Stephen E.,Varney, Michael D.,Reddy, M. Rami,Lewis, Kathleen K.,Kathardekar, Vinit,Mazdiyasni, Hormoz,Deal, Judith,Nguyen, Dzuy,Welsh, Katharine M.,Webber, Stephanie,Johnston, Amanda,Matthews, David A.,Smith, Ward W.,Janson, Cheryl A.,Bacquet, Russell J.,Howland, Eleanor F.,Booth, Carol L. J.,Herrmann, Steven M.,Ward, Robert W.,White, Jennifer,Bartlett, Charlotte A.,Morse, Cathy A.
, p. 677 - 683 (2007/10/03)
Six new diphenyl sulfoxide and five new diphenyl sulfones were designed, synthesized, and tested for their inhibition of human and Escherichia coli thymidylate synthase (TS) and of the growth of cells in tissue culture. The best sulfoxide inhibitor of hum
