4728-14-7

Usage

Uses

Used in Pharmaceutical Industry:
(2,2-dimethyl-5-nitro-1,3-dioxan-5-yl)methanol is used as an intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into complex organic molecules.
Used in Agrochemical Industry:
(2,2-dimethyl-5-nitro-1,3-dioxan-5-yl)methanol is used as an intermediate in the synthesis of agrochemicals, contributing to the development of new pesticides and other agricultural products.
Used in Chemical Industry:
(2,2-dimethyl-5-nitro-1,3-dioxan-5-yl)methanol is used as a building block for the production of nitroalkanes, which are commonly used as solvents and fuel additives.
Used as a Reagent:
(2,2-dimethyl-5-nitro-1,3-dioxan-5-yl)methanol is used as a reagent for the selective reduction of carbonyl compounds, enabling specific chemical transformations in organic synthesis.

InChI:InChI=1/C7H13NO5/c1-6(2)12-4-7(3-9,5-13-6)8(10)11/h9H,3-5H2,1-2H3

Upstream product

• 67-64-1 acetone 
• 126-11-4 2-hydroxymethyl-2-nitro-propane-1,3-diol 
• 109-63-7 trifluoroborane diethyl ether 
• 77-76-9 2,2-dimethoxy-propane 

Downstream Products

• 678992-55-7 2,2-dimethyl-5-nitro-5-(nitrobenzyl)-[1,3]-dioxane 
• 446-51-5 2-fluorobenzyl alcohol 
• 678992-56-8 2,2-dimethyl-5-(2-fluorobenzyl)-5-nitro-[1,3]-dioxane 
• 1449589-69-8 1-(2,2-dimethyl-5-nitro-1,3-dioxan-5-yl)-4-phenyl-1H-1,2,3-triazole 
• 107821-92-1 2,2-dimethyl-5-nitro-5-[4-(4-nitro-phenylsulfanyl)-phenylazo]-[1,3]dioxane 
• 104912-19-8 2,2-dimethyl-5-nitro-5-(4-nitro-phenylazo)-[1,3]dioxane 
• 104622-21-1 5-(4-chloro-phenylazo)-2,2-dimethyl-5-nitro-[1,3]dioxane 
• 106377-87-1 2,2-dimethyl-5-nitro-5-p-tolylazo-[1,3]dioxane 
• 104440-15-5 2,2-dimethyl-5-nitro-5-phenylazo-[1,3]dioxane 
• 53104-32-8 (5-amino-2,2-dimethyl-1,3-dioxan-5-yl)methanol 
• 25304-85-2 5-benzoyloximethyl-2,2-dimethyl-5-nitro-[1,3]dioxane 
• 4064-87-3 2,2-dimethyl-5-nitro-1,3-dioxane 
• 138435-94-6 5-<<(tert-Butyldiphenylsilyl)oxy>methyl>-2,2-dimethyl-5-nitro-1,3-dioxane 
• 139157-69-0 1-methyl 2-(2,2-dimethyl 1,3-dioxane 5-ylidenemethyl) 5-nitroimidazole 

Relevant academic research and scientific papers

Development of new methods for the synthesis of 2,3-bis(nitroxymethyl)-2,3-dinitrobutane-1,4-diol dinitrate and its intermediates

Known methods for the synthesis of 2,3-bis(nitroxymethyl)-2,3-dinitrobutane-1,4-diol dinitrate and its intermediates were investigated. New procedures were developed for the preparation of these compounds. 2,3-Bis(nitroxymethyl)-2,3-dinitrobutane-1,4-diol dinitrate was studied by X-ray diffraction.

Tris(hydroxymethyl)nitromethane in phospholipids synthesis

The tris(hydroxymethyl)nitromethane acetone derivative was applied as an initial compound for phospholipid syntheses. This ketal was converted in succession into the corresponding O,O- and O,N-cyclophosphites used further for preparation by the methods of organophosphorus chemistry of the first representatives from the following phospholipid types: phosphocholines, phosphomethylcolamines, diol phospholipids, and also cationic phospholipids. 2004 MAIK "Nauka/Interperiodica".

Polynitrocarbamates Derived from Nitromethane

A variety of energetic compounds combining nitro with nitrocarbamate groups were synthesized. The precursors, polynitro alcohols, were obtained by the condensation of the readily available starting material nitromethane with the small aliphatic aldehydes formaldehyde and glyoxal. The conversion into carbamates was achieved with the reactive chlorosulfonyl isocyanate (CSI) and a final nitration yielded the polynitrocarbamates. The new compounds were fully characterized, including multinuclear NMR spectroscopy, vibrational analysis, mass spectrometry, differential scanning calorimetry, and elemental analysis. The energies of formation were calculated with the GAUSSIAN program package and the detonation parameters were predicted using the EXPLO5 computer code. Due to the positive oxygen balance (ΩCO) of the presented compounds, their performance data as oxidizers were determined and compared to the common oxidizer ammonium perchlorate.

Synthesis of Substituted 6-(1H-1,2,3-Triazol-1-Yl)- 4,7-Dihydro-1,3,5-Dioxazepine

A convenient method was developed for the synthesis of 6-(1H-1,2,3-triazol-1-yl)-4,7-dihydro-1,3,5-dioxazepines, using deoxygenation of 1-(5-nitro-1,3-dioxan-5-yl)-1H-1,2,3-triazoles with triethyl phosphite.

Synthesis and crystal structure of 5,5'-dinitro-[5,5'-bi-(1,3,2- dioxathiane)]2,2'-dioxide

A novel 1,3,2-dioxathiane-2-oxide derivative 5,5'-dinitro-[5,5'-bis(1,3,2- dioxathiane)]2,2'-dioxide was synthesised. Moreover, the molecular structure of the compound was confirmed by the X-ray crystal structure determination.

A PROCESS FOR MAKING 2-NITRO-1-ETHANOL DERIVATIVES

A process for making a 2-nitro-1-ethanol derivative of formula III: wherein R3 is as described herein is provided. Novel 2-nitro-1-ethanol derivatives provided.

Efficient synthesis of a peculiar vicinal diamine semiochemical from streptomyces natalensis

(Equation Presented). The pimaricin-inducing (PI) factor, produced by Streptomyces natalensis is a proposed pheromone with a peculiar vicinal diamine structure. The first synthesis of this molecule is reported. It features oxidative dimerization of an aci-nitro anion derived from tris(hydroxymethyl) nitromethane and disproportionation catalyst-facilitated hydrogenation of the resulting vicinal tertiary dinitro compound. As the synthesis requires only four steps with no chromatographic separations, it provides a convenient route to prepare PI factor for biological studies and industrial applications.

Synthesis of heterocyclic geminal nitro azides

The oxidative azidation reactions of C-nitro-substituted saturated heterocyclic compounds, viz., the nitro derivatives of oxetane, azetidine, 1,3-dioxane, tetrahydro-1,3-oxazine, and hexahydropyrimidine, were investigated. A novel representatives of the geminal nitro azides were prepared and their physicochemical properties were studied. The process of the formation of the geminal dinitro compounds upon oxidative azidation was analyzed.

New submonomers for poly N-substituted glycines (peptoids)

Five protected submonomers for peptoid synthesis were prepared, including N(in)-BOC-tryptamine, O-t-butyl tyramine, PMC-guanidino- propylamine, 6-amino-6-deoxy-D-galactopyranose diacetonide, and 5-amino-2,2- dimethyl-1,3-dioxane. The first three mimic nat

Syntheses of 4-deoxy-D-fructose and enzymatic affinity study

Enantiomerically pure 4-deoxy-D-fructose has been prepared and characterised in a protected form, acidic hydrolysis of which led to an aqueous solution of 4-deoxy-D-fructose. Activities of this compound with enzymes of the glycolysis pathway involved in glucose metabolism make possible access to 4-deoxy-D-fructose-6-phosphate, 4-deoxy-D-glucose-6- phosphate and 4-deoxy-D-gluconate-6-phosphate.