4732-12-1

Basic information

• Product Name: O-ethylmenthol
• Synonyms: Brn 2518191;Einecs 225-237-9;Phenetole, 2-isopropyl-5-methyl-;O-ethylmenthol;1-Isopropyl-2-ethoxy-4-methylbenzene;2-Ethoxy-4-methyl-1-(1-methylethyl)benzene;Ethylthymyl ether;2-Isopropyl-5-methylphenethole
• CAS NO: 4732-12-1
• Molecular Formula: C₁₂H₁₈O
• Molecular Weight: 178.2707
• EINECS: 225-237-9
• Mol File: 4732-12-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 253°Cat760mmHg
• Flash Point: 91.7°C
• Appearance: /
• Density: 0.908g/cm³
• Vapor Pressure: 0.0298mmHg at 25°C
• Refractive Index: 1.488
• CAS DataBase Reference: O-ethylmenthol(CAS DataBase Reference)
• NIST Chemistry Reference: O-ethylmenthol(4732-12-1)
• EPA Substance Registry System: O-ethylmenthol(4732-12-1)

Safety Data

• Hazardous Substances Data: 4732-12-1(Hazardous Substances Data)

Usage

General Description

O-Ethylmenthol is a chemical compound that belongs to the class of menthol derivatives. It is a clear, colorless liquid with a minty aroma and taste, and is commonly used in the flavor and fragrance industry. O-ethylmenthol has cooling properties and is often used in oral care products such as toothpaste, mouthwashes, and chewing gum. It is also utilized in pharmaceutical applications, particularly in topical analgesic and anti-itch products. O-ethylmenthol is considered safe for use in these products when used within specified limits and guidelines set by regulatory bodies. Overall, O-ethylmenthol is a versatile compound with various applications in consumer products.

InChI:InChI=1/C12H18O/c1-5-13-12-8-10(4)6-7-11(12)9(2)3/h6-9H,5H2,1-4H3

Upstream product

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• 74-96-4 ethyl bromide 

Downstream Products

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• 858847-54-8 2-ethoxy-4-methyl-5-nitro-benzoic acid 

Relevant articles and documents

Synthesis and tyrosinase inhibitory activities of 4-oxobutanoate derivatives of carvacrol and thymol

Carvacrol (1) and thymol (2) were converted to their alkyl 4-oxobutanoate derivatives (7–20) in three steps, and evaluated for tyrosinase inhibitory activity. The compounds showed structure-dependent activity, with all alkyl 4-oxobutanoates, except 7 and 20, showing better inhibitory activity than the precursor 4-oxobutanoic acids (5 and 6). In general, thymol derivatives exhibited a higher percent inhibitory activity than carvacrol derivatives at 500 μM. Derivatives containing three-carbon and four-carbon alkyl groups gave the strongest activity (carvacrol derivatives 9–12, IC50 = 128.8–244.1 μM; thymol derivatives 16–19, IC50 = 102.3–191.4 μM).

Biotechnological Potential of Eugenol and Thymol Derivatives Against Staphylococcus aureus from Bovine Mastitis

Bovine mastitis is an infectious disease that affects the mammary gland of dairy cattle with considerable economic losses. Staphylococcus aureus is the main microorganism involved in this highly contagious process, and the treatment is only using antibiotics. Currently, the search for new treatment and/or compounds is still in need due to microbial resistance. In this work, we evaluated the potential of eugenol and thymol derivatives against S. aureus strains from bovine mastitis. On that purpose, nine derivatives were synthesized from eugenol and thymol (1–9), and tested against 15 strains of S. aureus from subclinical bovine mastitis. Initially, the strains were evaluated for the biofilm production profile, and those with strong adherence were selected to the antimicrobial sensitivity determination in the Minimum Inhibitory Concentration (MIC) assays. Herein the compounds toxicity was also evaluated by in silico analysis using Osiris DataWarrior software. The results showed that 60% of the strains were considered strongly adherent and three strains (S. aureus 4271, 4745 and 4746) were selected for the MIC tests. Among the nine eugenol and thymol derivatives tested, four were active against the evaluated strains (MIC = 32?μg?mL?1) within CLSI standard values. In silico analysis showed that all derivatives had cLopP ??4 and TPSA 140 ?2, and similar theoretical toxicity parameters to some antibiotics currently on the market. These molecules also showed negative drug-likeness values, pointing to the originality of these structures and theoretical feasibility on escaping of resistance mechanism and act against resistant strains. Thus, these eugenol derivatives may be considered as promising for the development of new treatments against bovine mastitis and future exploring on this purpose.

COMPOSITIONS AND METHODS FOR IMMUNE MODULATION AND TREATMENT OF CANCER

The disclosure relates to rexinoids, including compounds of the Formula (I) and (II) or a pharmaceutically acceptable salt, polymorph, prodrug, solvate or clathrate thereof. These rexinoids are useful for increasing PD-L1 in vivo, for treatment of cancer, and for inhibiting the onset of cancer.