473547-14-7Relevant academic research and scientific papers
Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: New potent non-competitive metabotropic glutamate receptor 2/3 antagonists. Part 1
Woltering, Thomas J.,Adam, Geo,Alanine, Alexander,Wichmann, Juergen,Knoflach, Frederic,Mutel, Vincent,Gatti, Silvia
, p. 6811 - 6815 (2008/04/03)
A series of 1,3-dihydrobenzo[b][1,4]diazepin-2-one derivatives was evaluated as non-competitive mGluR2/3 antagonists. Attachment of an 8-(2-aryl)-ethynyl-moiety produced compounds inhibiting the binding of [3H]-LY354740 to rat mGluR2 with low n
Dihydro-benzo [b][1,4]diazepin-2-one derivatives
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, (2008/06/13)
This invention is a dihydro-benzo[b][1,4]diazepin-2-one derivative of the formula wherein R1, R2, R3, X and Y are as defined in the specification. The invention includes pharmaceutical compositions containing these compounds, a process for their preparation, their use in preparation of pharmaceutical compositions and administration of an effective amount of the compounds for the treatment or prevention of acute and/or chronic neurological disorders to a patient in need of such treatment.
