473987-30-3Relevant academic research and scientific papers
Synthetic approach to tetrodotoxin
Itoh, Tetsuji,Watanabe, Manabu,Fukuyama, Tohru
, p. 1323 - 1325 (2002)
A novel and stereoselective approach to tetrodotoxin is described. The tricyclic compound having several key functional groups on the cyclohexane ring was synthesized from p-anisaldehyde with control of the four chiral centers. Iodoaminocyclization, 1,3-dipolar cycloaddition, and Baeyer-Villiger oxidation are the key steps of our approach.
