14954-72-4Relevant academic research and scientific papers
Rapid palladium-catalyzed cross-coupling in the synthesis of aryl thioethers under microwave conditions
Cai, Lisheng,Cuevas, Jessica,Peng, Yi-Yuan,Pike, Victor W.
, p. 4449 - 4452 (2006)
A Pd-catalyzed coupling of aromatic iodides or bromides and tin-thiolates under microwave conditions was developed to synthesize aromatic thioethers without concomitant formation of the reduced products. Ligand screening revealed DiPPF and BINAP-Tol as th
Heterogeneously copper-catalyzed oxidative synthesis of imidazo[1,2-a]pyridines using 2-aminopyridines and ketones under ligand- and additive-free conditions
Meng, Xu,Wang, Yanmin,Yu, Chaoying,Zhao, Peiqing
, p. 27301 - 27307 (2014/07/21)
An efficient and mild heterogeneously CuCl2/nano-TiO 2-catalyzed aerobic synthesis of imidazo[1,2-a]pyridines from 2-aminopyridines and ketones has been developed using air as the oxidant in the absence of any ligands and additives. This strategy was compatible with a large range of substrates, including unactivated aryl ketones and unsaturated ketones and went through the C-H bond functionalization mechanism instead of I --assisted Ortoleva-King reaction to provide the corresponding imidazo[1,2-a]pyridines in good yields with low catalyst loading (0.8 mol%). Moreover, the heterogeneous catalyst can be successfully employed in gram-scale synthesis and reused many times without the significant loss of catalytic activity.
BETA-AMYLOID PET IMAGING AGENTS
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Page/Page column 37; 39, (2008/06/13)
Novel derivatives of imidazopyridinylbenzeneamines and novel derivatives of benzothiazolylbenzeneamines are disclosed that offer improved behavior when used as imaging agents for positron emission tomography of beta-amyloids. Also disclosed is a palladium-catalyzed reaction scheme under microwave conditions for aryl thioethers in general that provides a high ratio of substitution relative to reduction and can be used for the imidazopyridinylbenzeneamine derivatives as well as other compounds of related structure.
Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting β-amyloid plaques in the brain
Zhuang, Zhi-Ping,Kung, Mei-Ping,Wilson, Alan,Lee, Chi-Wan,Pl?ssl, Karl,Hou, Catherine,Holtzman, David M.,Kung, Hank F.
, p. 237 - 243 (2007/10/03)
A series of novel β-amyloid (Aβ) aggregate-specific ligands, 2-(4′-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyridine, 16(IMPY), and its related derivatives were prepared. An in vitro binding study with preformed Aβ aggregates showed that 16(IMPY) and its
Substituent effects on fluorescent properties of imidazo[1,2- α]pyridine-based compounds
Tomoda, Haruhiko,Hirano, Takafumi,Saito, Shojiro,Mutai, Toshiki,Araki, Koji
, p. 1327 - 1334 (2007/10/03)
In order to search for novel fluorescent organic compounds, 20 derivatives of imidazo[1,2-a]pyridine (1) were synthesized, and their fluorescent properties were studied. Though the parent compound I (λ(fl) = 370.5 nm, Φ = 0.57 in ethanol) was in the liquid state at ambient temperature, 2-phenylimidazo[1,2-a]pyridine (5), 2-(2-naphthyl)imidazo[1,2- a]pyridine (16), 7-methylimidazo[1,2-a]pyridine (3), 7-methyl-2- phenylimidazo[1,2-a]pyridine (12), and 7-methyl-2(2-naphthyl)imidazo[1,2- a]pyridine (17) were found to give thermally stable solid compounds (mp 55- 190 °C) without much affecting the fluorescent properties of the parent compound (λ(fl) = 374-381 nm, Φ = 0.50-0.78 in ethanol). Among the 4'- substituted 2-phenyl derivatives, it was found that the introduction of the strong electron-donating amino and dimethylamino groups (2-(4- aminophenyl)imidazo[1,2-a]pyridine (7) and 2-[4- (dimethylamino)phenyl]imidazo[1,2-a]pyridine (8), respectively) caused marked red shift of their fluorescence (λ(fl) = 445 and 446 nm, respectively, in ethanol), thus providing the way for tuning the fluorescence color of the IP derivatives. The observed red shift of the fluorescence of 7 and 8 was ascribed to the contribution of the excited intramolecular charge transfer state.
