474013-81-5

Upstream product

• 75-64-9 tert-butylamine 
• 474013-77-9 5,10-dioxo-5H,10H-diimidazolo[1,5-a:1',5'-d]pyrazine-1,6-dicarboxylic acid diphenyl ester 
• 59157-06-1 4H,9H-diimidazo<1,5-a; 1',5'-d>pyrazine-5,10-dione-1,6-dicarboxylic dichloride 
• 570-22-9 4,5-imidazoledicarboxylic acid 

Relevant academic research and scientific papers

An improved method for the synthesis of dissymmetric N,N′-disubstituted imidazole-4,5-dicarboxamides

Symmetrically and dissymmetrically disubstituted imidazole-4,5-dicarboxamides (I45DCs) have diverse bioactivities and therefore represent useful small molecules for lead structure identification in drug discovery. For this reason, an improved synthesis was developed as a first step in the preparation of greater numbers of analogues. The method involves the transformation of imidazole-4,5-dicarboxylic acid into dissymmetrically disubstituted I45DCs in four steps and in a minimum yield of 51%. This reflects an overall reduction of one synthetic step and a greater than 30% improvement in yield over the known method.