4741-58-6

Basic information

• Product Name: 4,5-Dimethoxyphthalide
• Synonyms: 4,5-Dimethoxyphthalide;4,5-Dimethoxyisobenzofuran-1(3H)-one
• CAS NO: 4741-58-6
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 194.18
• Mol File: 4741-58-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 122-123 °C
• Boiling Point: 404.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.260±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4,5-Dimethoxyphthalide(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-Dimethoxyphthalide(4741-58-6)
• EPA Substance Registry System: 4,5-Dimethoxyphthalide(4741-58-6)

Safety Data

• Hazardous Substances Data: 4741-58-6(Hazardous Substances Data)

Usage

General Description

4,5-Dimethoxyphthalide is a chemical compound with the molecular formula C10H10O4. It is a phthalide derivative and is characterized by the presence of two methoxy groups on the aromatic ring. 4,5-Dimethoxyphthalide is known for its potential biological activities and is being studied for its pharmaceutical properties. It has been found to exhibit antimicrobial, antifungal, and anti-inflammatory properties. It also has potential as an antioxidant and has shown promising results in various studies. Additionally, 4,5-Dimethoxyphthalide has been investigated for its potential use in drug development for the treatment of conditions such as cancer, cardiovascular diseases, and neurological disorders. Overall, this compound is of interest for its diverse pharmacological potential and is a subject of ongoing research in the field of medicinal chemistry.

Upstream product

• 1567-56-2 3,4-dimethoxyphthalic anhydride 
• 201230-82-2 carbon monoxide 
• 5653-67-8 2,3-dimethoxybenzyl alcohol 
• 74785-03-8 (6-iodo-2,3-dimethoxyphenyl)methanol 
• 50-00-0 formaldehyd 
• 22792-13-8 4-(3’,4’-dimethoxybenzoyl)morpholine 
• 623-27-8 terephthalaldehyde, 
• 110451-87-1 2-bromomethyl-1-iodo-4,5-dimethoxybenzene 
• 123796-70-3 3,4-dimethoxy-2-carbethoxybenzoic acid 
• 7732-18-5 water 
• 518-90-1 3,4-dimethoxy-phthalic acid 
• 57193-17-6 4,4-dimethyl-2-(3,4-dimethoxyphenyl)-2-oxazoline 
• 1522-67-4 N-phenyl-3,4-dimethoxybenzamide 

Downstream Products

• 518-90-1 3,4-dimethoxy-phthalic acid 
• 6279-83-0 3,4-dimethoxy-6-nitro-phthalic acid 

Relevant articles and documents

Synthesis of 3-Unsubstituted Phthalides from Aryl Amides and Paraformaldehyde via Ruthenium(II)-Catalyzed C–H Activation

A straightforward and convenient route has been developed for the synthesis of 3-unsubstituted phthalide derivatives from aryl amides and paraformaldehyde by ruthenium(II)-catalyzed C–H activation. The reaction proceeds through tandem ortho-hydroxymethylation of aryl amide and subsequent intramolecular lactonization.

SYNTHESIS OF (Z)-3-BUTYLIDENE-6,7-DIHYDROXYPHTHALIDE

(Z)-3-Butylidene-6,7-dihydroxyphthalide (2) was first synthesized from 6,7-dimethoxyphthalide (4) and its structure was synthetically confirmed.

COBALT-CATALYSED CARBONYLATION OF ARYL HALIDES

A novel method for carbonylation of aromatic and heteroatomatic halides is described.The catalytic system consists of a combination of alkylcobalt carbonyl complexes, either performed or made "in situ", and bases such as alkoxides, NaOH and K2CO3 in aliphatic alcohols.Under these conditions new anionic cobalt complexes are formed which are characterized by a very high reactivity towards aromatic halides.The latter undergo the carbonylation reaction with high yield under very mild conditions.