4743-68-4

Upstream product

• 4411-89-6 (E/Z)-2-phenylcrotonaldehyde 
• 75-16-1 methylmagnesium bromide 
• 40596-14-3 3-phenylpent-4-en-2-ol 
• 917-64-6 methyl magnesium iodide 
• 4411-89-6 2-phenyl-2-butenal 
• 71-41-0 pentan-1-ol 
• 82176-57-6 α-bromo-β-methylstyrene 
• 75-07-0 acetaldehyde 
• 93-55-0 1-phenyl-propan-1-one 

Downstream Products

• 92686-59-4 C₂₀H₁₉NS₂ 
• 92686-59-4 C₂₀H₁₉NS₂ 
• 87567-35-9 1-(Neophylsulfonyl)-3-phenyl-(E)-pent-3-ene 
• 87567-37-1 C₂₁H₂₆O₂S 
• 37580-41-9 3-Phenyl-1,3-pentadiene 

Relevant academic research and scientific papers

Enantioselective Nickel-Catalyzed Alkyne-Azide Cycloaddition by Dynamic Kinetic Resolution

The triazole heterocycle has been widely adopted as an isostere for the amide bond. Many native amides are α-chiral, being derived from amino acids. This makes α-N-chiral triazoles attractive building blocks. This report describes the first enantioselective triazole synthesis that proceeds via nickel-catalyzed alkyne-azide cycloaddition (NiAAC). This dynamic kinetic resolution is enabled by a spontaneous [3,3]-sigmatropic rearrangement of the allylic azide. The 1,4,5-trisubstituted triazole products, derived from internal alkynes, are complementary to those commonly obtained by the related CuAAC reaction. Initial mechanistic experiments indicate that the NiAAC reaction proceeds through a monometallic Ni complex, which is distinct from the CuAAC manifold.

Reductive cleavage of 2-methyleneoxetanes with lithium and 4,4'-di-tert- butylbiphenyl

3,3-Dimethyl-2-mcthylene-4-phenyloxetane (5) undergoes reductive cleavage with lithium and 4,4'-di-tertbutylbiphenyl (DTBB) to give an intermediate dianion, which reacts regioselectively with aldehydes and ketones to give aldol adducts in modest yields. A

Regio- and Stereoselective Hydrosulfonylation of Conjugated Dienes via a (?-Allyl)palladium Complex

The combination of a sulfonylpalladation of acyclic dienes 1 (with 2 equiv of NaSO2R and 1 equiv of PdCl2 in acetic acid or acetic acid-H2O at 50-80 deg C under air) and a protiodepalladation of the thus obtained palladium complexes 3 with dimethylglyoxime (in a protic solvent at room temperature) provides di- and trisubstituted (Z)-Δ3-sulfones 12 selectively, irrespective of the stereochemistry of the starting dienes.Similar treatment of 1-vinylcycloalkenes 5 (n (1,3) strain between Pd and the substituent on the allylic position.