474378-40-0Relevant academic research and scientific papers
Ultrasonic assisted synthesis of 2, 3-dihydroquinazolin-4(1H)-ones involving three-component reaction of isatoic anhydride, amines and pyrazole carbaldehydes catalyzed by [?-fe2o3?hap-So3H]
Mahmoodi, Nosrat O.,Moghadam, Kurosh R.,Nikpassand, Mohammad,Rasa, Mahdi,Sina, Kiana F.,Yahyazadeh, Asieh
, p. 24 - 30 (2020)
The combination of [?-Fe2O3?HAp-SO3H] as a catalyst and ultrasonic effect catalyzed the synthesis of diverse derivatives of 2, 3-dihydroquinazolin-4(1H)-ones which is reported in this study. The products were synthesized via the one-pot three-component reaction of isatoic anhydride, amines and pyrazole carbaldehydes in water: EtOH catalyzed by recoverable [?-Fe2O3?HAp-SO3H]. This paper conducted an investigation of the effect of various solvents, temperatures and catalysts on the reactions. Short reaction times, mild reaction conditions, simple work-up, the desired yields and the use of an appropriate catalyst are the advantages of this novel method. The new derivatives were validated by using FT-IR,1HNMR, and13CNMR. Moreover, the synthesized compounds were screened for their an-timicrobial activity against bacterial strains.
L-Proline catalyzed one-pot multi-component synthesis of 2-(1,3-diphenyl-1H-pyrazol-4-yl)quinazolin-4(3H)-one derivatives and their biological studies
Mehta, Hemal B.,Dixit, Bharat C.,Dixit, Ritu B.
supporting information, p. 741 - 744 (2014/06/09)
A new series of quinazolin-4(3H)-one derivatives containing a (1,3-diphenyl-1H-pyrazol-4-yl) core with substituents at the 2-position and aromatic or heteroaromatic substituents at the 3-position were synthesized using an l-proline catalyzed one-pot multi-component reaction approach. All the synthesized compounds were characterized and screened for their antimicrobial, antifungal and anti-tubercular activities.
