475272-46-9

Upstream product

• 475272-44-7 3-(4-hydroxy-3,2''-diisobutyl-2'-naphthalen-1-ylmethyl-[1,1':4',1'']-terphenyl-4''-yl)propionitrile 
• 107-14-2 chloroacetonitrile 
• 475272-45-8 3-(4-cyanomethoxy-3,2''-diisobutyl-2'-naphthalen-1-ylmethyl-[1,1':4',1'']-terphenyl-4''-yl)propionitrile 
• 434300-54-6 4-(2-cyanoethyl)-2-isobutylphenyl trifluoromethanesulfonate 
• 25016-01-7 5-bromo-2-methoxybenzaldehyde 
• 90-11-9 1-Bromonaphthalene 
• 475272-37-8 (5-bromo-2-methoxy-phenyl)-naphthalene-1-yl-methanol 
• 475272-38-9 1-(5-bromo-2-methoxybenzyl)-naphthalene 
• 475272-43-6 3-(3,2''-diisobutyl-4-methoxy-2'-naphthalen-1-ylmethyl-[1,1':4',1'']-terphenyl-4''-yl)propionitrile 
• 475272-42-5 trifluoro-methanesulfonic acid 4'-(2-cyano-ethyl)-2'-isobutyl-3-naphthalen-1-ylmethyl-biphenyl-4-yl-ester 
• 475272-40-3 3-(2-isobutyl-4'-methoxy-3'-naphthalen-1-yl-methylbiphenyl-4-yl)propionitrile 
• 475272-41-4 3-(4'-hydroxy-2-isobutyl-3'-naphthalen-1-ylmethylbiphenyl-4-yl)-propionitrile 
• 475272-39-0 2-(4-methoxy-3-naphthalene-1-ylmethyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane 
• 475272-04-9 2-(3-isobutyl-4-methoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane 

Relevant academic research and scientific papers

Proteomimetic compounds and methods

The present invention relates to compounds and pharmaceutical compositions which are proteomimetic and to methods for inhibiting the interaction of an alpha-helical protein with another protein or binding site. Methods for treating diseases or conditions which are modulated through interactions between alpha helical proteins and their binding sites are other aspects of the invention.

Development of a potent Bcl-xL antagonist based on α-helix mimicry

The rational design of low-molecular weight ligands that disrupt protein-protein interactions is still a challenging goal in medicinal chemistry. Our approach to this problem involves the design of molecular scaffolds that mimic the surface functionality