476-46-0Relevant articles and documents
Braun
, p. 2885 (1979)
The Chemical Structure and the Mutagenicity of Emodin Metabolites
Morooka, Nobuhisa,Nakano, Sonoko,Itoi, Noriko,Ueno, Yoshio
, p. 1247 - 1252 (2007/10/02)
Emodin (1,3,8-trihydroxy-6-methyl-9,10-anthraquinone) is a natural occuring anthraquinone formed in rhubarb and fungal metabolites.Emodin was transformed into 6 major metabolites by rat hepatic microsomes.The metabolites were identified as 2-hydroxyemodin, 4-hydroxyemodin, 5-hydroxyemodin, 7-hydroxyemodin, ω-hydroxyemodin, and emodic acid by comparison with the synthetic compounds using thin-layer chromatography.It was clear that 2-hydroxyemodin is a proximate mutagen as a synthetic compound by the Salmonella assay.Other metabolites, such as 5-hydroxyemodin and ω-hydroxyemodin, became active after metabolic activation, but 4-hydroxyemodin and emodic acid were inactive either in the presence or in the absence of the metabolic activation system.
Regioselective synthesis of the naturally occurring anthraquinones digitopurpone, islandicin, catenarin, and erythroglaucin
Braun
, p. 2247 - 2257 (2007/10/02)
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