476318-99-7

Upstream product

• 110691-01-5 6-amino-4-(4-methoxyphenyl)-2-thioxo-1,2-dihydropyridine-3,5-dicarbonitrile 
• 74-88-4 methyl iodide 
• 123-11-5 4-methoxy-benzaldehyde 
• 13623-94-4 1,1-di(methylsulfanyl)-2-nitroethylene 
• 109-77-3 malononitrile 
• 2826-26-8 2-(4-methoxyphenylmethylene)malononitrile 
• 110691-01-5 2-amino-4-(4-methoxyphenyl)-6-mercaptopyridine-3,5-dicarbonitrile 
• 79359-42-5 2-amino-4-(4-methoxyphenyl)-6-(phenylsulfanyl) pyridine-3,5-dicarbonitrile 

Downstream Products

• 131695-26-6 3,6-diamino-4-(4-methoxyphenyl)-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile 

Relevant academic research and scientific papers

Reactions with dimethylformamide-dimethylacetal: Synthesis and reactions of several new pyrjdjne and pyrazolo[3,4-&]pyridine derivatives

6-Aminopyridine-2(1H)-thiones 1a,b reacted with dimethylformamide- dimethylacetal (DMF-DMA) to give the corresponding 6-{[(N,N-dimethylamino) methylene]amino}pyridine derivatives 2a,b. The latter compounds reacted with hydrazine hydrate to afford the 3,6-

Preclinical Evaluation of the First Adenosine A1 Receptor Partial Agonist Radioligand for Positron Emission Tomography Imaging

Central adenosine A1 receptor (A1R) is implicated in pain, sleep, substance use disorders, and neurodegenerative diseases, and is an important target for pharmaceutical development. Radiotracers for A1R positron emission t

One-pot Four-component Synthesis of Highly Functionalized Pyridines Using Nitroketene Dithioacetal as a Source of Methyl Thiolate Under Solvent-free Condition

A simple method for the synthesis of highly functionalized 2-amino-6-(methylthio)pyridine-3,5-dicarbonitriles is presented. In this method, pyridine derivatives are synthesized from the reaction of malononitrile, aromatic aldehydes, nitroketene dithioacetal in the presence of ethylene diamine. The notable features of this method are the simple Experimental procedure, short reaction time, and good yields.