476418-18-5

Upstream product

• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 78847-04-8 (2E,4E,6E)-2,4,6-trimethyl-7-(4-nitro-phenyl)-hepta-2,4,6-trienal 
• 476418-12-9 ethyl (2E,4E,6E)-2,4,6-trimethyl-7-(4-nitrophenyl)hepta-2,4,6-trienoate 
• 648414-16-8 (2E,4E,6E)-2,4,6-trimethyl-7-(4-nitrophenyl)hepta-2,4,6-trien-1-ol 
• 555-16-8 4-nitrobenzaldehdye 
• 59488-85-6 (2E,4E)-2,4-dimethyl-5-(4-nitrophenyl)penta-2,4-dienol 
• 59488-84-5 (2E,4E)-2,4-dimethyl-5-(p-nitrophenyl)pentan-2,4-dienal 
• 22388-91-6 ethyl (2E,4E)-2,4-dimethyl-5-(4-nitrophenyl)penta-2,4-dienoate 
• 37542-81-7 (2E)-2-methyl-3-(4-nitrophenyl)prop-2-en-1-ol 
• 58550-34-8 (E)-2-methyl-3-(4-nitrophenyl)acrylaldehyde 

Relevant academic research and scientific papers

Biomimetic studies on polyenes.

The crispatenes and SNF4435 C&D are complex polypropionate derived natural products. The core structures of these compounds along with a complex unnatural structure can be easily prepared from a common polyene precursor simply by variation of the reaction conditions. The reaction pathways provide insight into the biosynthesis of these complex natural products.

Studies on the biomimetic synthesis of SNF4435 C and D

(equation Presented) The biomimetic synthesis of the bicyclic core of the novel immunosuppresants SNF4435C and SNF4435D is reported. The core framework was efficiently generated from the all-trans tetraene precursor in one step and in good yield.