477338-27-5

Upstream product

• 477338-23-1 methyl methyl 2-(1-butoxyvinyl)-4,5-dimethoxybenzoate 
• 477338-25-3 2-(2-Bromo-acetyl)-4,5-dimethoxy-benzoic acid 
• 477338-24-2 methyl 2-acetyl-4,5-dimethoxybenzoate 
• 58657-20-8 4',5'-Dimethoxy-2'-carboxyacetophenon 
• 17667-32-2 methyl 6-bromo-3,4-dimethoxybenzoate 
• 19193-05-6 3,4-dihydro-4-keto-6,7-dimethoxyisocoumarin 
• 552-89-6 2-nitro-benzaldehyde 

Downstream Products

• 221189-56-6 2-hydroxy-6,7-dimethoxy-3-(2-nitrophenyl)-1,4-naphthoquinone 

Relevant academic research and scientific papers

Palladium-catalyzed synthesis of o-acetylbenzoic acids: A new, efficient general route to 2-hydroxy-3-phenyl-1,4-naphthoquinones and indolo[2,3-b]naphthalene-6,11-diones

We describe here a new, efficient general synthesis of o-acetylbenzoic acids by Heck palladium-catalyzed arylation of n-butyl vinyl ether with o-bromobenzoic acid esters and the use of these compounds as starting materials for the synthesis of 3-benzylideneisochroman-1,4-diones, which readily rearrange to 2-hydroxy-3-phenyl-1,4-naphthoquinones. The application of this strategy to the synthesis of indolo[2,3-b]naphthalene-6,11-diones is also described.