477600-68-3

Basic information

• Product Name: (3S,4S)-1-benzyl-N,4-dimethylpiperidin-3-amine hydrochloride
• Synonyms: (3S,4S)-1-benzyl-N,4-dimethylpiperidin-3-amine hydrochloride;1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE;1-Benzyl-N,4-diMethylpipe...;3-PiperidinaMine,N,4-diMethyl-1-(phenylMethyl)-, hydrochloride (1:2), (3R,4R)-rel-;cis-1-Benzyl-N-Methyl-4-Methylpiperidin-3-aMine dihydrochloride;(3R,4R)-rel-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine dihydrochloride;(3R,4R)-1-benzyl-N,4-diMethylpiperidin-3-aMine (2R,3R)-2,3-bis((4-Methylbenzoyl)oxy)succinic acid;(3R,4R)-rel-1-Benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
• CAS NO: 477600-68-3
• Molecular Formula: C14H22N2.2(HCl)
• Molecular Weight: 0
• Mol File: 477600-68-3.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (3S,4S)-1-benzyl-N,4-dimethylpiperidin-3-amine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,4S)-1-benzyl-N,4-dimethylpiperidin-3-amine hydrochloride(477600-68-3)
• EPA Substance Registry System: (3S,4S)-1-benzyl-N,4-dimethylpiperidin-3-amine hydrochloride(477600-68-3)

Safety Data

• Hazardous Substances Data: 477600-68-3(Hazardous Substances Data)

Usage

Uses

(3R,4R)-rel-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine Dihydrochloride is used as a reagent in the preparation of cis-3-Methylamino-4-methylpiperidines and also in synthesis of piperidine derivatives as immunosuppressant for the treatment of diseases associated with pathologic JAK3 activation.

InChI:InChI:1S/C14H22N2.2ClH/c1-12-8-9-16(11-14(12)15-2)10-13-6-4-3-5-7-13;;/h3-7,12,14-15H,8-11H2,1-2H3;2*1H

Upstream product

• 1354621-59-2 cis-N-benzyl-3-methoxycarbonylamino-4-methylpiperidine 
• 77862-24-9 4-Methyl-3-(methylamino)pyridine 
• 3430-27-1 3-amino-4-methylpyridine 
• 32018-96-5 1-benzyl-4-methyl-piperidin-3-one 
• 32018-56-7 1-benzyl-4-methyl-1 ,2,3,6-tetrahydropyridine 
• 923036-28-6 (1-benzyl-4-methyl-1,2,5,6-tetrahydropyridin-3-yl)carbamic acid methyl ester 
• 1354621-59-2 (3S,4S)-1-benzyl-N,4-dimethylpiperidin-3-amine 
• 6998-30-7 methylamine acetate 
• 1228879-37-5 C₁₄H₂₂N₂*ClH 
• 50-00-0 formaldehyd 
• 1039738-27-6 1-benzyl-4-methyl-3-amino piperidine 
• 100-44-7 benzyl chloride 

Relevant articles and documents

Investigation of practical routes for the kilogram-scale production of cis-3-methylamino-4-methylpiperidines

Two routes for the synthesis of cis-N-protected-3-methylamino-4- methylpiperidine (3) were examined: a route hinging on the electrochemical oxidation of carbamate 1 to install a ketone at the 3 position of the piperidine followed by reductive animation (disconnection A), and a route involving the hydrogenation of an appropriately functionalized pyridine (disconnection B). While both routes to the desired compound were ultimately successful, the pyridine hydrogenation approach proved to be more amenable to kilogram-scale preparations due to the crystallinity and purity of intermediates in that route.

Synthesis and application of 1-benzyl-4-methyl-5-alkoxy-1, 2, 3, 6-tetrahydropyridine derivative

The invention relates to the field of synthesis of drug intermediates, in particular to the field of synthesis of key intermediates for preparing anti-rheumatoid arthritis drug tofacitinib, and specifically relates to a 1-benzyl-4-methyl-5-alkoxy-1, 2, 3, 6-tetrahydropyridine compound, a synthetic method thereof, and an application of the 1-benzyl-4-methyl-5-alkoxy 1, 2, 3, 6-tetrahydropyridine compound in preparation of a key intermediate cis-1-benzyl-3-methylamino-4-methyl piperidine of tofacitinib.

Tropsch process for cloth intermediate (3 R, 4 R) - N, 4 - dimethyl -1 - benzyl -3 - amino piperdine and its oxalate salt hydrate of new synthetic method

The invention relates to a supporting france for cloth intermediate (3 R, 4 R) - N, 4 - dimethyl - 1 - benzyl - 3 - amino piperdine and its oxalate salt hydrate of new synthetic method. In order to 3 - amino - 4 - methyl pyridine as the starting material, its amino with orthoformate [...] is generated by the reaction, after after simple concentration, for the metal borohydride reduction to obtain N - methyl derivatives; Boc protection after the, re-covering and into a quaternary ammonium salt, the metal borohydride reduction, then the Rh catalyst for selective hydrogenation, form an enriched (3 R, 4 R - rel -) configuration of compounds, hydrochloric acid/alcohol system deprotected and into salt splitting removing (3 R, 4 S - rel -) isomer to, the resulting (3 R, 4 R - rel -) configuration product for free after L - DTTA obtained through splitting 3 R, 4 R - configuration product; splitting the resulting salts are free after through, into the oxalate purification, to further remove the residual small amount of 3 S, 4 S - isomer so as to obtain a corresponding high-purity and high optical purity (3 R, 4 R) - N, 4 - dimethyl - 1 - benzyl - 3 - amino piperdine. The method of the invention more beneficial for safe, simple and convenient of industrialized scale preparation Tropsch process for cloth intermediate (3 R, 4 R) - N, 4 - dimethyl - 1 - benzyl - 3 - amino piperdine oxalic acid salt hydrate.