77862-24-9

Basic information

• Product Name: 4-METHYL-3-METHYLAMINOPYRIDINE
• Synonyms: 4-METHYL-3-METHYLAMINOPYRIDINE;N,4-Dimethylpyridin-3-amine;N,4-diMethyl-3-PyridinaMine;3-PyridinaMine, N,4-diMethyl-;Methyl-(4-methyl-pyridin-3-yl)-amine
• CAS NO: 77862-24-9
• Molecular Formula: C₇H₁₀N₂
• Molecular Weight: 122.17
• Product Categories: Pyridines
• Mol File: 77862-24-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 237.125 °C at 760 mmHg
• Flash Point: 97.21 °C
• Appearance: /
• Density: 1.032 g/cm³
• Vapor Pressure: 0.046mmHg at 25°C
• Refractive Index: 1.569
• PKA: 7.19±0.18(Predicted)
• CAS DataBase Reference: 4-METHYL-3-METHYLAMINOPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-3-METHYLAMINOPYRIDINE(77862-24-9)
• EPA Substance Registry System: 4-METHYL-3-METHYLAMINOPYRIDINE(77862-24-9)

Safety Data

• Hazardous Substances Data: 77862-24-9(Hazardous Substances Data)

Usage

General Description

4-Methyl-3-methylaminopyridine is a chemical compound that belongs to the class of aminopyridines. It is a yellow to brown solid that is soluble in organic solvents such as ethanol and acetone. 4-METHYL-3-METHYLAMINOPYRIDINE is commonly used as a catalyst in organic reactions and as a building block in the synthesis of pharmaceuticals and agrochemicals. It is also a key intermediate in the manufacturing of dyes, pigments, and other fine chemicals. Additionally, 4-methyl-3-methylaminopyridine has been studied for its potential application in the field of materials science, particularly in the development of functionalized polymers and biomaterials. However, it is important to handle this chemical with care as it can be hazardous if not used properly.

InChI:InChI=1/C7H10N2/c1-6-3-4-9-5-7(6)8-2/h3-5,8H,1-2H3

Upstream product

• 74-89-5 methylamine 
• 3430-22-6 3-Bromo-4-methylpyridin 
• 593-51-1 methylamine hydrochloride 
• 72093-04-0 3-chloro-4-methylpyridine 
• 3430-27-1 3-amino-4-methylpyridine 
• 124-41-4 sodium methylate 
• 694495-63-1 O-methyl-N-(4-methylpyridin-3-yl)carbamate 

Downstream Products

• 161563-35-5 1-methyl-2-oxo-3H-pyrrolo<2,3-c>pyridine 
• 1615709-89-1 1-benzyl-4-methyl-3-(methylamino)pyridinium bromide 
• 1354621-59-2 cis-N-benzyl-3-methoxycarbonylamino-4-methylpiperidine 
• 1228879-37-5 (3R,4R)-rel-N,4-dimethyl-1-benzyl-3-piperidinamine dihydrochloride 
• 1206824-89-6 tert-butyl methyl(4-methylpiperidin-3-yl)carbamate 
• 1228879-37-5 cis-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride 
• 384338-23-2 (1-benzyl-4-methyl-piperidin-3-yl)-methyl-amine 

Relevant articles and documents

Preparation method of tofacitinib intermediate cis-1-benzyl-N, 4-dimethylpiperidine-3-amine dihydrochloride

The invention discloses a preparation method of a tofacitinib intermediate cis-1benzyl-N, 4-dimethyl piperidine-3-amine dihydrochloride. The synthetic method comprises the following steps: taking 3-bromo-4-methylpyridine as an initial raw material, performing substitution reaction with amine to obtain a compound III, and performing acetyl or tert-butyloxycarbonyl protection and catalytic hydrogenation on the compound III to obtain a piperidine compound V. The compound V and benzaldehyde are subjected to reductive amination or react with benzyl halide to obtain a compound VI. A protecting groupis removed from the compound VI, and a hydrochloride compound I. 2HCl is formed at the same time. The synthesis method is simple to operate, high in total yield, high in product purity, stable in quality and suitable for industrial production.

Synthesis method for preparing intermediates of tofacitinib

The invention provides a novel method for synthesizing primary ring cis-4-methyl-3-methylamino-1-benzylpiperidine bis-hydrochloride of tofacitinib. The primary ring cis-4-methyl-3-methylamino-1-benzylpiperidine bis-hydrochloride is made from 3-halogenation-picoline. The novel method includes steps of catalytic Ullman coupling, 3-halogenation-picoline and benzyl halide salifying, hydroboration reagent reduction, salifying and the like to obtain target compounds. The method has the advantages of simple conditions, easily available reagents and operational safety.

A synthetic cis - 1 - benzyl - 3 - methylamino - 4 - methyl - piperidine

The invention relates to a method for synthesizing cis-1-benzyl-3-methylamino-4-methyl-piperidine, in particular to a method for synthesizing cis-1-benzyl-3-methylamino-4-methyl-piperidine by taking 1-benzyl-3-methylamino-4-methyl-piperidine bromide as an