477775-73-8Relevant academic research and scientific papers
SUPRAMOLECULAR PROTEIN ASSEMBLIES WITH ADVANCED FUNCTIONS AND SYNTHESIS THEREOF
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, (2019/05/18)
The present invention discloses stimuli-sensitive protein conjugate which can make supramolecular protein assemblies and methods for using the same. The present invention provides simple and rational process for construction of said stimuli-sensitive spherical protein assemblies through supramolecular chemical strategy.
Solid Phase Stepwise Synthesis of Polyethylene Glycols
Khanal, Ashok,Fang, Shiyue
supporting information, p. 15133 - 15142 (2017/10/31)
Polyethylene glycol (PEG) and derivatives with eight and twelve ethylene glycol units were synthesized by stepwise addition of tetraethylene glycol monomers on a polystyrene solid support. The monomer contains a tosyl group at one end and a dimethoxytrityl group at the other. The Wang resin, which contains the 4-benzyloxy benzyl alcohol function, was used as the support. The synthetic cycle consists of deprotonation, Williamson ether formation (coupling), and detritylation. Cleavage of PEGs from solid support was achieved with trifluoroacetic acid. The synthesis including monomer synthesis was entirely chromatography-free. PEG products including those with different functionalities at the two termini were obtained in high yields. The products were analyzed with ESI and MALDI-TOF MS and were found close to monodispersity.
Precursor for preparing micelle
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Paragraph 0062-0065; 0180; 0181, (2016/11/21)
The present invention refers to linker, polar material and two aliphatic hydrocarbon chain comprised of precursor for micellar formation, said precursor manufacturing method, including micelles and including said precursor of said micelle relates to drug delivery. In the present invention number the use of precursor for forming micelle under public affairs, two game machine included in same, non-polar tail due to, than micelles of the existing method a relatively high stability of the insertion part and the holder under trillion number micelle, micelles including drug delivery or the like and can be widely used for the development of.. (by machine translation)
Highly efficient synthesis of monodisperse poly(ethylene glycols) and derivatives through macrocyclization of oligo(ethylene glycols)
Zhang, Hua,Li, Xuefei,Shi, Qiuyan,Li, Yu,Xia, Guiquan,Chen, Long,Yang, Zhigang,Jiang, Zhong-Xing
, p. 3763 - 3767 (2015/03/18)
A macrocyclic sulfate (MCS)-based approach to monodisperse poly(ethylene glycols) (M-PEGs) and their monofunctionalized derivatives has been developed. Macrocyclization of oligo(ethylene glycols) (OEGs) provides MCS (up to a 62-membered macrocycle) as versatile precursors for a range of monofunctionalized M-PEGs. Through iterative nucleophilic ring-opening reactions of MCS without performing group protection and activation, a series of M-PEGs, including the unprecedented 64-mer (2850Da), can be readily prepared. Synthetic simplicity coupled with versatility of this new strategy may pave the way for broader applications of M-PEGs. Macrocycles make synthesis easier: Convenient macrocyclization of the OEGs provides versatile macrocyclic sulfates. These compounds are cornerstones for both monofunctionalization of OEGs and highly efficient synthesis of monodisperse PEGs and derivatives, including an unprecedented 64-mer.
Development of a Scalable Process for α-Amino-ω-methoxyl-dodecaethylene Glycol
Xia, Guiquan,Li, Yu,Yang, Zhigang,Jiang, Zhong-Xing
, p. 1769 - 1773 (2015/12/01)
We have developed a process for the efficient and scalable preparation of heterofunctionalized dodecaethylene glycol from the readily available tetraethylene glycol and its macrocyclic sulfate. By employing the benzyl group as both a protecting group and a separative tag, multiple chromatographic separations were avoided. With this method, α-amino-ω-methyl-dodecaethylene glycol was prepared on a 53 g scale with high purity and 61% overall yield in eight steps and one chromatographic separation.
A practical and scalable process to selectively monofunctionalize water-soluble α,ω-diols
Zhang, Quanxuan,Ren, Hong,Baker, Gregory L.
, p. 3384 - 3386 (2014/06/09)
A practical protocol for rapid and scalable synthesis of monofunctionalized α,ω-diols using a simple and inexpensive THP ether protection/deprotection strategy was described. Use of inexpensive DHP source and ease to remove excess water-soluble α,ω-diols
Synthesis of a library of propargylated and PEGylated α-hydroxy acids toward "clickable" polylactides via hydrolysis of cyanohydrin derivatives
Zhang, Quanxuan,Ren, Hong,Baker, Gregory L.
, p. 9546 - 9555 (2015/02/19)
A new simple and practical protocol for scalable synthesis of a novel library of propargylated and PEGylated α-hydroxy acids toward the preparation of "clickable" polylactides was described. The overall synthesis starting from readily available propargyl alcohol, bromoacetaldehyde diethyl acetal, and OEGs or PEGs was developed as a convenient procedure with low cost and no need of column chromatographic purification. The terminal alkyne functionality survives from hydrolysis of the corresponding easily accessible cyanohydrin derivatives in methanolic sulfuric acid. Facile desymmetrization, monofunctionalization, and efficient chain-elongation coupling of OEGs further enable the incorporation of OEGs to α-hydroxy acids in a simple and efficient manner. At the end, synthesis of allyloxy lactic acid indicates that an alkene group is also compatible with the developed method. (Chemical Equation Presented).
Synthesis of gemini surfactants with twelve symmetric fluorine atoms and one singlet 19F MR signal as novel 19F MRI agents
Li, Yu,Thapa, Bijaya,Zhang, Hua,Li, Xuefei,Yu, Fanghua,Jeong, Eun-Kee,Yang, Zhigang,Jiang, Zhong-Xing
, p. 9586 - 9590 (2013/10/22)
A family of fluorinated gemini surfactants derived from perfluoropinacol has been synthesized as novel 19F magnetic resonance imaging ( 19F MRI) agents. These fluorinated surfactants with 12 symmetric fluorine atoms and one singlet
Application of a water-soluble pyridyl disulfide amine linker for use in Cu-free click bioconjugation
Thomas, Joshua D.,Burke Jr., Terrence R.
, p. 4316 - 4319 (2011/09/12)
Described herein is the design and synthesis of a discrete heterobifunctional PEG-based pyridyl disulfide/amine-containing linker that can be used in the Cu-free click preparation of bioconjugates. The title PEG-based pyridyl disulfide amine linker is a potentially useful reagent for preparing water-soluble disulfide-linked cargos, and that it may be particularly valuable in expanding the field of Cu-free click-based bioconjugations to include reductively labile antibody, polymer, or nanoparticle-based drug conjugates.
High-purity discrete PEG-oligomer crystals allow structural insight
French, Alister C.,Thompson, Amber L.,Davis, Benjamin G.
supporting information; experimental part, p. 1248 - 1252 (2009/06/30)
To great (monodisperse) lengths: An improved synthesis of purer ethylene glycol (EG) oligomers allows access to 16- and 32-mers pure enough for multiple incorporation, and also to the longest (48-mer) discrete EG oligomer yet reported. The high purity enables the first crystallizations and hence the first glimpses of secondary 310-helical PEG structures.
