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Usage

Uses

Used in Pharmaceutical Synthesis:
1-Chloro-2-nitro-4-(phenylsulfonyl)benzene is used as an intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the introduction of functional groups, making it a key component in the development of new drugs with potential therapeutic applications.
Used in Agrochemical Production:
1-Chloro-2-nitro-4-(phenylsulfonyl)benzene also serves as an intermediate in the synthesis of agrochemicals, contributing to the development of effective pesticides and other agricultural products that enhance crop protection and yield.
Used as a Reagent in Organic Synthesis:
1-Chloro-2-nitro-4-(phenylsulfonyl)benzene is utilized as a reagent in organic synthesis, particularly for the production of biologically active compounds. Its presence in reactions can facilitate the formation of complex organic molecules with specific biological properties.
Used in the Synthesis of Aromatic Compounds:
The nitro group in 1-Chloro-2-nitro-4-(phenylsulfonyl)benzene makes it a valuable building block for the synthesis of diverse aromatic compounds, which are important in various chemical and pharmaceutical applications.
Overall, 1-Chloro-2-nitro-4-(phenylsulfonyl)benzene is a versatile and important intermediate in the field of organic chemistry, with applications spanning across pharmaceuticals, agrochemicals, and organic synthesis for the production of biologically active compounds and aromatic compounds.

Upstream product

• 97-08-5 3-nitro-4-chlorosulfonyl chloride 
• 71-43-2 benzene 
• 858842-47-4 toluene-4-sulfonic acid-(4-benzenesulfonyl-2-nitro-anilide) 
• 858005-35-3 toluene-4-sulfonic acid-(4-benzenesulfonyl-anilide) 
• 70415-93-9 1,4-bis-benzenesulfonyl-2-nitro-benzene 
• 896-80-0 1-benzenesulfonyl-2,4-dinitro-benzene 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 7019-01-4 p-aminophenyl phenyl sulfone 

Downstream Products

• 100727-93-3 4-benzenesulfonyl-1-methoxy-2-nitro-benzene 
• 860557-40-0 4-benzenesulfonyl-2-nitro-1-(toluene-4-sulfonyl)-benzene 
• 70415-93-9 1,4-bis-benzenesulfonyl-2-nitro-benzene 
• 2493-66-5 2-nitro-4-phenylsulfonylphenol 
• 102542-98-3 bis-(4-benzenesulfonyl-2-nitro-phenyl)-sulfide 
• 915763-82-5 2-nitro-4-(phenylsulphonyl)-1-(trifluoromethyl)benzene 
• 915763-83-6 5-(phenylsulphonyl)-2-(trifluoromethyl)aniline 
• 39070-66-1 2-nitro-4-(phenylsulphonyl)aniline 
• 117644-58-3 N-(2-Azepan-1-yl-5-benzenesulfonyl-phenyl)-acetamide 
• 117644-47-0 3-phenylsulphonyl-6H-7,8,9,10-tetrahydroazepino<1.2-a>benzimidazole 
• 117644-57-2 3-amino-4-hexahydroazepin-1-ylphenyl phenyl sulphone 
• 101605-59-8 Phenyl-<3-nitro-4-phenoxy-phenyl>-sulfon 
• 91955-91-8 (4-benzenesulphonyl-2-nitro-phenyl)-N-methylamine 
• 95169-38-3 3-Nitro-4-<4-methoxy-anilino>-diphenylsulfon 

Relevant academic research and scientific papers

Manufacturing method of piperidinyl sulfonyl sulfonamide

The present invention relates to the preparation of diphenylsulfonylamide represented by formula 1. Chemically 1 _AOMARKENCODEGTX06017. A compound represented by chemical formula 2 is obtained by reacting a compound represented by chemical formula 3 with N-protected piperidine amine to obtain a compound represented by the following formula, wherein N is protected with N-protected piperidine amine to obtain a compound represented by chemical formula 4 6, and to obtain a compound represented by the 6 7 formula 5 of the compound represented by the following general formula in the following 7 chemical formula 5 to obtain a compound represented by the following general formula (1 I). AOMARKENCODELTX017. Chemically 2 _AOMARKENCODEGTX06017. AOMARKENCODELTX017. Chemically 3 _AOMARKENCODEGTX06017. AOMARKENCODELTX017. Chemically 4 _AOMARKENCODEGTX06017. AOMARKENCODELTX017. Chemically 5 _AOMARKENCODEGTX06017. AOMARKENCODELTX017. Chemically 6 _AOMARKENCODEGTX06017. AOMARKENCODELTX017. Chemically 7 _AOMARKENCODEGTX06017.

Synthesis and biological evaluation of optimized inhibitors of the mitotic kinesin Kif18A

The mitotic spindle, a highly dynamic structure composed of microtubules, mediates the segregation of the previously duplicated genome into the two nascent daughter cells. Errors in this process contribute to pathology including tumor formation. Key for the shape and function of the mitotic spindle are kinesins, molecular motor proteins that convert chemical energy into mechanical work. Due to their fast mode of action, small molecules are valuable tools to dissect the dynamic functions of kinesins during mitosis. In this study, we report the identification of optimized small molecule inhibitors of the mitotic kinesin Kif18A. Using BTB-1, the first identified Kif18A inhibitor, as a lead compound, we synthesized a collection of derivatives. We demonstrate that some of the synthesized derivatives potently inhibited the ATPase activity of Kif18A with a half maximal inhibitory concentration (IC50) value in the low micromolar range. In vitro analysis of a panel of Kif18A-related kinesins revealed that the two most potent compounds show improved selectivity compared to BTB-1. Structure-activity relationship studies identified substituents mediating undesired inhibitory effects on microtubule polymerization. In summary, our study provides key insights into the mechanism of action of BTB-1 and its analogs, which will have a great impact on the further development of highly selective and bioactive Kif18A inhibitors. Since Kif18A is frequently overexpressed in solid tumors, such compounds are not only of great interest for basic research but also have the potential to open up new strategies for the treatment of human diseases.

Modulation of Wnt signaling through inhibition of secreted frizzled-related protein i (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides

The diphenylsulfonyl sulfonamide scaffold represented by 1 (WAY-316606) are small molecule inhibitors of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. Modulators of the Wnt pathway have been proposed as anabolic a

PIPERIDINYL ARYLSULFONE DERIVATIVES AS MODULATORS OF SECRETED FRIZZLED RELATED PROTEIN-1

Compounds of Formula (1), or pharmaceutically acceptable salts thereof, are provided: which are modulators of secreted frizzled related protein- 1. The compounds, and compositions containing the compounds, can be used to treat a variety of disorders, including osteoporosis.

2H-Benzimidazoles (Isobenzimidazoles). Part 3. Thermal Isomerisation of Substituted 2H-Benzimidazoles to 1H-Benzimidazoles

2H-Benzimidazole-2-spirocyclohexanes (1) when heated undergo a 1,5-sigmatropic rearrangement to 2,3-disubstituted 1H-benzimidazoles.A decided effect on the direction of this isomerisation was observed with substituents in the homodiene ring.