478082-32-5Relevant articles and documents
Iminomalonate as a convenient electrophilic amination reagent for grignard reagents
Niwa, Yasuki,Takayama, Kazuki,Shimizu, Makoto
, p. 1819 - 1825 (2002)
Diethyl 2-[N-(p-methoxyphenyl)imino]malonate underwent amination reactions with alkyl Grignard reagents to give N-aklylation products in good yields. The obtained N-alkylation products were readily converted into N-alkyl-panisidines by the oxidative removal of the malonate moiety. The p-methoxyphenyl group was subsequently deprotected to give primary amines.
Conjugated imines and iminium salts as versatile acceptors of nucleophiles
Shimizu, Makoto,Hachiya, Iwao,Mizota, Isao
scheme or table, p. 874 - 889 (2009/07/10)
Growing interests in nitrogen-containing molecules involving bioactive and functional materials have stimulated the recent development of synthetic methodologies where nucleophilic addition reactions to imino carbons are utilized in crucial steps. This article summarizes double nucleophilic addition reactions with α,β-unsaturated aldimines, addition reactions using alkynyl imines, "umpoled" reactions of α-imino esters, and the use of iminium salts as reactive electrophiles. The Royal Society of Chemistry 2009.