478148-60-6

Usage

Uses

Used in Pharmaceutical Industry:
Furo[2,3-c]pyridine-5-methanol (9CI) is utilized as a key intermediate in the development of novel drug molecules, capitalizing on its unique structural features to enhance the therapeutic potential of new pharmaceuticals.
Used in Organic Synthesis:
In the realm of organic synthesis, Furo[2,3-c]pyridine-5-methanol (9CI) serves as a valuable building block, facilitating the creation of complex organic compounds and contributing to the advancement of chemical research.
Used in Chemical Research:
Furo[2,3-c]pyridine-5-methanol (9CI) is employed as a subject of study in chemical research, where its properties and reactivity are investigated to expand the understanding of fused heterocyclic systems and their role in chemical and biological processes.

Upstream product

• 208519-39-5 (7-chlorofuro[2,3-c]pyridin-5-yl)methanol 
• 952587-20-1 {5-hydroxy-4-[(trimethylsilyl)ethynyl]-2-pyridinyl}methyl acetate trifluoroacetate 
• 956010-20-1 [2-(trimethylsilyl)furo[2,3-c]pyridin-5-yl]methyl acetate 
• 478148-59-3 5-hydroxymethyl-2-trimethylsilyl-furo[2,3-c]pyridine 
• 952587-18-7 {5-({[4-(methyloxy)phenyl]methyl}oxy)-4-[(trimethylsilyl)ethynyl]-2-pyridinyl}methyl acetate 
• 724788-78-7 (5-({[4-(methyloxy)phenyl]methyl}oxy)-4-{[(trifluoromethyl)sulfonyl]oxy}-2-pyridinyl)methyl acetate 
• 441044-90-2 [7-chloro-2-(trimethylsilyl)furo[2,3-c]pyridin-5-yl]methanol 
• 208519-38-4 2-chloro-6-(hydroxymethyl)-4-[(trimethylsilyl)ethynyl]-3-pyridinol 
• 208519-37-3 2-chloro-3-hydroxy-6-(hydroxymethyl)-4-iodopyridine 
• 208519-41-9 2-chloro-6-(hydroxymethyl)-3-pyridinol 
• 6636-78-8 2-chloro-3-hydroxypyridine 
• 478149-20-1 furo[2,3-c]pyridin-5-yl methyl acetate 

Downstream Products

• 944407-44-7 2H,3H-furo[2,3-c]pyridin-5-ylmethanol 
• 478148-61-7 furo[2,3-c]pyridine-5-carbaldehyde 
• 872715-05-4 2,3-dihydrofuro[2,3-c]pyridine-5-carbaldehyde 
• 478149-53-0 PHA-543613 
• 478148-62-8 furo[2,3-c]pyridine-5-carboxylic acid 

Relevant academic research and scientific papers

CARBINOL DERIVATIVES HAVING HETEROCYCLIC LINKER

[Object] It is to provide a novel LXRβ agonist useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. [Solving Means] A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate: (wherein, each V and W independently show N or C—R7; each X and Y independently show CH2, C═O, SO2, etc; Z shows CH or N; each R1, R2 and R7 independently show a hydrogen atom, C1-8 alkyl group, etc.; R3 shows C1-8 alkyl group; R4 shows an optionally substituted C6-10 aryl group or an optionally substituted 5- to 11-membered heterocyclic group; R5 and R6 show a hydrogen atom, etc.; L shows a C1-8 alkyl chain optionally substituted with an oxo group, etc.; and n shows any integer of 0 to 2.)

The design of efficient and selective routes to pyridyl analogues of 2,3-dihydro-1,4-benzodioxin-6-carbaldehyde

This Letter describes the synthetic routes to challenging pyridyl analogues of 2,3-dihydro-1,4-benzodioxin- 6-carbaldehyde which were key intermediates for our antibacterial medicinal chemistry programme. All routes described started from kojic acid (8) and have been used to give multigram quantities of each aldehyde.

DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES

Bicyclic nitrogen containing compounds and their use as antibacterials.

TRICYCLIC NITROGEN CONTAINING HETEROCYCLES AS ANTIBACTERIAL AGENTS

Tricyclic nitrogen containing compounds and their use as antibacterials.

Pyrrolo[3,2,1-ij]quinoline-4-one derivatives for treating tuberculosis

Tricyclic nitrogen-containing compounds of Formula (I) and pharmaceutically acceptable derivatives thereof: compositions containing them, their use in the treatment of tuberculosis, and methods for the preparation of such compounds.

TRYCLIC NITROGEN CONTAINING COMPOUNDS AND THEIR USE AS ANTIBACTERIALS

Tricyclic nitrogen containing compounds of formula (I) and their use as antibacterials.

PYRROLO-QUINOXALINONE DERIVATIVES AS ANTIBACTERIALS

Tricyclic nitrogen containing compounds of the following Formula (I) and their use as antibacterials.

Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5- carboxamide, an agonist of the α7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: Synthesis and structure-activity relationship

N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide (14, PHA-543,613), a novel agonist of the α7 neuronal nicotinic acetylcholine receptor (α7 nAChR), has been identified as a potential treatment of cognitive deficits in schizophrenia. Compound 14 is a potent and selective a7 nAChR agonist with an excellent in vitro profile. The compound is characterized by rapid brain penetration and high oral bioavailability in rat and demonstrates in vivo efficacy in auditory sensory gating and, in an in vivo model to assess cognitive performance, novel object recognition.

CRYSTALLINE FUMARATE SALTS OF 1-AZABICYCLO[2.2.2]OCT SUBSTITUTED FURO[2,3-C]PYRIDINYL CARBOXAMIDE AND COMPOSITIONS AND PREPARATIONS THEREOF

The invention provides fumarate salts of N-[1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, compositions, racemic mixtures, or pure enantiomers thereof, and preparation thereof. The fumarate salts are useful to treat diseases or conditions in which α7 nAChR is known to be involved. Formula (I).