478148-61-7

Usage

Uses

Used in Pharmaceutical Synthesis:
Furo[2,3-c]pyridine-5-carboxaldehyde (9CI) is utilized as a key intermediate in the development of pharmaceuticals, contributing to the creation of various medicinal compounds due to its ability to participate in a range of organic reactions.
Used in Agrochemical Production:
In the agrochemical industry, Furo[2,3-c]pyridine-5-carboxaldehyde (9CI) serves as an essential component in the synthesis of pesticides and other agrochemicals, enhancing their effectiveness in agricultural applications.
Used in Organic Chemistry Research:
Furo[2,3-c]pyridine-5-carboxaldehyde (9CI) is employed as a research chemical, facilitating the exploration of new organic reactions and the development of innovative synthetic pathways in organic chemistry.
Used in Industrial Applications:
Its versatile chemical properties position Furo[2,3-c]pyridine-5-carboxaldehyde (9CI) as a valuable intermediate in various industrial processes, where it is used to produce a wide array of organic compounds for different purposes.

Upstream product

• 478148-60-6 furo[2,3-c]pyridin-5-yl methanol 
• 441044-90-2 [7-chloro-2-(trimethylsilyl)furo[2,3-c]pyridin-5-yl]methanol 
• 478148-59-3 5-hydroxymethyl-2-trimethylsilyl-furo[2,3-c]pyridine 
• 79-37-8 oxalyl dichloride 
• 208519-38-4 2-chloro-6-(hydroxymethyl)-4-[(trimethylsilyl)ethynyl]-3-pyridinol 
• 208519-37-3 2-chloro-3-hydroxy-6-(hydroxymethyl)-4-iodopyridine 
• 208519-39-5 (7-chlorofuro[2,3-c]pyridin-5-yl)methanol 
• 208519-41-9 2-chloro-6-(hydroxymethyl)-3-pyridinol 
• 6636-78-8 2-chloro-3-hydroxypyridine 

Downstream Products

• 478148-62-8 furo[2,3-c]pyridine-5-carboxylic acid 
• 478149-53-0 PHA-543613 

Relevant academic research and scientific papers

CARBINOL DERIVATIVES HAVING HETEROCYCLIC LINKER

[Object] It is to provide a novel LXRβ agonist useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. [Solving Means] A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate: (wherein, each V and W independently show N or C—R7; each X and Y independently show CH2, C═O, SO2, etc; Z shows CH or N; each R1, R2 and R7 independently show a hydrogen atom, C1-8 alkyl group, etc.; R3 shows C1-8 alkyl group; R4 shows an optionally substituted C6-10 aryl group or an optionally substituted 5- to 11-membered heterocyclic group; R5 and R6 show a hydrogen atom, etc.; L shows a C1-8 alkyl chain optionally substituted with an oxo group, etc.; and n shows any integer of 0 to 2.)

Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5- carboxamide, an agonist of the α7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: Synthesis and structure-activity relationship

N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide (14, PHA-543,613), a novel agonist of the α7 neuronal nicotinic acetylcholine receptor (α7 nAChR), has been identified as a potential treatment of cognitive deficits in schizophrenia. Compound 14 is a potent and selective a7 nAChR agonist with an excellent in vitro profile. The compound is characterized by rapid brain penetration and high oral bioavailability in rat and demonstrates in vivo efficacy in auditory sensory gating and, in an in vivo model to assess cognitive performance, novel object recognition.

CRYSTALLINE FUMARATE SALTS OF 1-AZABICYCLO[2.2.2]OCT SUBSTITUTED FURO[2,3-C]PYRIDINYL CARBOXAMIDE AND COMPOSITIONS AND PREPARATIONS THEREOF

The invention provides fumarate salts of N-[1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, compositions, racemic mixtures, or pure enantiomers thereof, and preparation thereof. The fumarate salts are useful to treat diseases or conditions in which α7 nAChR is known to be involved. Formula (I).

Quinuclidines-substituted-multi-cyclic-heteroaryls for the treatment of disease

The invention provides compounds of Formula I: 1where in W is 2These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula I are useful to treat diseases or conditions in which α7 is known to be involved.

Substituted 7-aza[2.2.1]bicycloheptanes for the treatment of disease

The invention provides compounds of Formula I: which may be in the form of pharmaceutical acceptable salts or compositions, are useful in treating diseases or conditions in which α7 nicotinic acetylcholine receptors (nAChRs) are known to be involved.

Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease

The invention provides compounds of Formula I: wherein Azabicyclo is These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula I are useful in pharmaceuticals in which α7 is known to be involved.