478303-56-9

Upstream product

• 478303-36-5 (2,4,5-trimethoxy-3-methylphenyl)acetic acid 
• 77515-73-2 (2,4,5-trimethoxy-3-methylphenyl)acetonitrile 
• 96502-90-8 acetic acid 2,4-dimethoxy-3-methyl-phenyl ester 
• 77515-72-1 1-chloromethyl-2,4,5-trimethoxy-3-methylbenzene 
• 25576-97-0 2,3,6-trimethoxytoluene 
• 10139-84-1 1-(2,4-dihydroxy-3-methylphenyl)ethanone 
• 69469-91-6 1-(2-hydroxy-4-methoxy-3-methylphenyl)ethanone 
• 608-25-3 2-methylbenzene-1,3-diol 
• 19676-67-6 2,4-dimethoxy-3-methylphenol 
• 60512-80-3 2′,4′-dimethoxy-3′-methylacetophenone 
• 40217-17-2 (R)-4-(phenylmethyl)-2-oxazolidinone 

Relevant academic research and scientific papers

Synthesis of a Diels-Alder precursor for the Elisabethin A skeleton

A synthesis of a precursor 2 for the Elisabethin A skeleton is reported. Containing a masked quinone and a (E,Z)-diene sub-unit, it has the required elements for the envisaged intramolecular Diels-Alder reaction to form the tricyclic system of Elisabethin A. Starting from methylresorcinol, the sequence involves the preparation of an arylacetic acid, which was α-alkylated by a chiral building block. Subsequent HWE reaction and cis-selective Wittig olefination furnished the diene with the desired geometry.