77515-73-2

Upstream product

• 77515-72-1 1-chloromethyl-2,4,5-trimethoxy-3-methylbenzene 
• 69469-91-6 1-(2-hydroxy-4-methoxy-3-methylphenyl)ethanone 
• 10139-84-1 1-(2,4-dihydroxy-3-methylphenyl)ethanone 
• 25576-97-0 2,3,6-trimethoxytoluene 
• 96502-90-8 acetic acid 2,4-dimethoxy-3-methyl-phenyl ester 
• 19676-67-6 2,4-dimethoxy-3-methylphenol 
• 60512-80-3 2′,4′-dimethoxy-3′-methylacetophenone 
• 7677-24-9 trimethylsilyl cyanide 
• 608-25-3 2-methylbenzene-1,3-diol 

Downstream Products

• 84018-46-2 2-(2,4,5-Trimethoxy-3-methylphenyl)ethylamine 
• 478303-36-5 (2,4,5-trimethoxy-3-methylphenyl)acetic acid 
• 478303-56-9 (R)-4-benzyl-3-[2-(2,4,5-trimethoxy-3-methylphenyl)acetyl]oxazolidin-2-one 
• 73777-65-8 (5,8-dihydro-7-methoxy-6-methyl-5,8-dioxo-1-isoquinolinyl)methyl (2Z)-2-methyl-2-butenoate 
• 77515-74-3 [2-(2,4,5-Trimethoxy-3-methyl-phenyl)-ethyl]-carbamic acid benzyl ester 
• 77515-75-4 5,7,8-Trimethoxy-6-methyl-3,4-dihydro-1H-isoquinoline-1,2-dicarboxylic acid 2-benzyl ester 1-methyl ester 

Relevant academic research and scientific papers

Synthesis of a Diels-Alder precursor for the Elisabethin A skeleton

A synthesis of a precursor 2 for the Elisabethin A skeleton is reported. Containing a masked quinone and a (E,Z)-diene sub-unit, it has the required elements for the envisaged intramolecular Diels-Alder reaction to form the tricyclic system of Elisabethin A. Starting from methylresorcinol, the sequence involves the preparation of an arylacetic acid, which was α-alkylated by a chiral building block. Subsequent HWE reaction and cis-selective Wittig olefination furnished the diene with the desired geometry.