25576-97-0

Upstream product

• 5673-07-4 2,6-dimethoxytoluene 
• 81574-49-4 2,4-dimethoxy-3-methylbenzoic acid 
• 6248-20-0 2,4-dihydroxy-3-methylbenzaldehyde 
• 7149-92-0 2,4-dimethoxy-3-methylbenzaldehyde 
• 96502-90-8 acetic acid 2,4-dimethoxy-3-methyl-phenyl ester 
• 10139-84-1 1-(2,4-dihydroxy-3-methylphenyl)ethanone 
• 608-25-3 2-methylbenzene-1,3-diol 
• 60512-80-3 2′,4′-dimethoxy-3′-methylacetophenone 
• 69469-91-6 1-(2-hydroxy-4-methoxy-3-methylphenyl)ethanone 
• 7722-84-1 dihydrogen peroxide 
• 135-77-3 1,2,4-trimethoxy-benzene 
• 74-88-4 methyl iodide 
• 19676-67-6 2,4-dimethoxy-3-methylphenol 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 60059-09-8 2,4,5-trimethoxy-3-methylbenzaldehyde 
• 2207-57-0 2-methoxy-3-methyl-1,4-benzoquinone 
• 77357-34-7 4,5-Dinitro-2,3,6-trimethoxytoluene 
• 72796-36-2 2-Methyl-3,4,4-trimethoxycyclohexa-2,5-dienone 
• 152532-88-2 1,2,4-trimethoxy-3-methyl-5-nitrobenzene 
• 1760-80-1 2-methoxy-3-methylbenzene-1,4-diol 
• 77357-46-1 2-methoxy-3-methyl-1,4-phenylene diacetate 
• 77357-45-0 5-Bromo-5-methyl-6-methoxy-6-acetoxycyclohex-2-ene-1,4-dione 
• 77357-49-4 3,4-Dibromo-2,5,6-trimethoxytoluene 
• 1384864-05-4 C₂₃H₂₅NO₅ 
• 1384864-04-3 C₁₆H₁₉NO₅ 
• 1384864-03-2 C₁₃H₁₅BrO₄ 
• 1384864-02-1 1-bromo-2-iodo-3,4,6-trimethoxy-5-methylbenzene 
• 1384864-01-0 C₁₆H₂₀N₂O₅ 

Relevant academic research and scientific papers

Formal Total Synthesis of Hybocarpone Enabled by Visible-Light-Promoted Benzannulation

The formal total synthesis of hybocarpone was achieved in eight steps from commercially available 1,2,4-trimethoxybenzene. Key transformations include a visible-light-promoted benzannulation to construct the key α-naphthol intermediate and a modified CAN-mediated dimerization/hydration cascade sequence to generate the vicinal all-carbon quaternary centers in a stereocontrolled manner. The total synthesis of boryquinone was also achieved in seven steps.

Catalytic Asymmetric Crotylation of Aldehydes: Application in Total Synthesis of (-)-Elisabethadione

A new, highly efficient Lewis base catalyst for a practical enantio- and diastereoselective crotylation of unsaturated aldehydes with E- and Z-crotyltrichlorosilanes has been developed. The method was employed as a key step in a novel asymmetric synthesis of bioactive serrulatane diterpene (-)-elisabethadione. Other strategic reactions for setting up the stereogenic centers included anionic oxy-Cope rearrangement and cationic cyclization. The synthetic route relies on simple, high yielding reactions and avoids use of protecting groups or chiral auxiliaries.

Formal synthesis of 7-methoxymitosene and synthesis of its analog via a key PtCl2-catalyzed cycloisomerization

A formal synthesis of 7-methoxymitosene is achieved via a key platinum-catalyzed cycloisomerization. The precursor for the Pt catalysis, a fully functionalized benzene intermediate, was prepared via a regioselective electrophilic bromination followed by a

Synthesis of 1,2,4-trimethoxybenzene and its selective functionalization at C-3 by directed metalation

A new and efficient strategy was developed for the preparation of 1,2,4-trimethoxybenzene (3, a powerful attractant of Euglossini bees) and its C-3 derivatives (7a-j), from vanillin (2) in 56% overall yield.

Enantioselective synthesis of the sporolide quinone acid fragment

The sporolide quinone acid is a key fragment in the biosynthesis of the complex heptacyclic marine metabolite sporolide. We report a concise enantioselective route to this fragment, which is obtained in seven steps with 65% overall yield from trimethoxybe

Gold(I)-catalyzed intramolecular [4+2] cycloadditions of arylalkynes or 1,3-enynes with alkenes: Scope and mechanism

The cyclizations of enynes substituted at the alkyne gives products of formal [4+2] cyclization with Au(I) catalysts. 1,8-Dien-3-ynes cyclize by a 5-exo-dig pathway to form hydrindanes. 1,6-Enynes with an aryl ring at the alkyne give 2,3,9,9a-tetrahydro-1

Rust disease control by Aphanocladium album and/or Beauveria brongniartii

There is disclosed a method and composition for controlling rust disease in plants. Metabolites produced by Aphanocladium album mycoparasites are recovered and applied in an effective amount to plants at risk for acquiring rust disease More specifically,

Combined C-H activation/cope rearrangement as a strategic reaction in organic synthesis: Total synthesis of (-)-colombiasin A and (-)-elisapterosin B

The total synthesis of (-)-colombiasin A (2) and (-)-elisapterosin B (3) has been achieved. The key step is a C-H functionalization process, the combined C-H activation/Cope rearrangement, between methyl (E)-2-diazo-3-pentenoate and 1-methyl-1,2-dihydrona

Synthesis of a Diels-Alder precursor for the Elisabethin A skeleton

A synthesis of a precursor 2 for the Elisabethin A skeleton is reported. Containing a masked quinone and a (E,Z)-diene sub-unit, it has the required elements for the envisaged intramolecular Diels-Alder reaction to form the tricyclic system of Elisabethin A. Starting from methylresorcinol, the sequence involves the preparation of an arylacetic acid, which was α-alkylated by a chiral building block. Subsequent HWE reaction and cis-selective Wittig olefination furnished the diene with the desired geometry.

ortho-Directed metallation in the regiocontrolled synthesis of enantiopure 2- and/or 3-substituted (S)S (p-tolylsulfinyl)-1,4-benzoquinones

Enantiomerically pure (S)S-(p-tolylsulfinyl)-1,4-benzoquinones with alkyl and methoxy substituents at C-2 and/or C-3 are synthesized by CAN oxidation of adequately substituted (S)S-(p-tolylsulfinyl)-1,4-dimethoxyaromatic precursors 2 or 3. These compounds were obtained by ortho-directed metallation or bromo-metal exchange from the corresponding p-methoxyanisoles in a highly regiocontrolled manner.