25576-97-0Relevant articles and documents
Formal Total Synthesis of Hybocarpone Enabled by Visible-Light-Promoted Benzannulation
Chen, Wei,Guo, Renyu,Yang, Zhen,Gong, Jianxian
, p. 15524 - 15532 (2018)
The formal total synthesis of hybocarpone was achieved in eight steps from commercially available 1,2,4-trimethoxybenzene. Key transformations include a visible-light-promoted benzannulation to construct the key α-naphthol intermediate and a modified CAN-mediated dimerization/hydration cascade sequence to generate the vicinal all-carbon quaternary centers in a stereocontrolled manner. The total synthesis of boryquinone was also achieved in seven steps.
Formal synthesis of 7-methoxymitosene and synthesis of its analog via a key PtCl2-catalyzed cycloisomerization
Liu, Lianzhu,Wang, Yanzhao,Zhang, Liming
scheme or table, p. 3736 - 3739 (2012/09/21)
A formal synthesis of 7-methoxymitosene is achieved via a key platinum-catalyzed cycloisomerization. The precursor for the Pt catalysis, a fully functionalized benzene intermediate, was prepared via a regioselective electrophilic bromination followed by a
Enantioselective synthesis of the sporolide quinone acid fragment
Wach, Jean-Yves,Gademann, Karl
scheme or table, p. 2849 - 2851 (2010/03/03)
The sporolide quinone acid is a key fragment in the biosynthesis of the complex heptacyclic marine metabolite sporolide. We report a concise enantioselective route to this fragment, which is obtained in seven steps with 65% overall yield from trimethoxybe
