478410-84-3Relevant academic research and scientific papers
Small-sized human immunodeficiency virus type-1 protease inhibitors containing allophenylnorstatine to explore the s2′ pocket
Hidaka, Koushi,Kimura, Tooru,Abdel-Rahman, Hamdy M.,Nguyen, Jeffrey-Tri,McDaniel, Keith F.,Kohlbrenner, William E.,Molla, Akhteruzzaman,Adachi, Motoyasu,Tamada, Taro,Kuroki, Ryota,Katsuki, Noriko,Tanaka, Yoshiaki,Matsumoto, Hikaru,Wang, Jun,Hayashi, Yoshio,Kempf, Dale J.,Kiso, Yoshiaki
experimental part, p. 7604 - 7617 (2010/05/18)
A series of HIV protease inhibitor based on the allophenylnorstatine structure with various P2′ moieties were synthesized. Among these analogues, we discovered that a small allyl group would maintain potent enzyme inhibitory activity compared t
Therapeutic combinations
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Page/Page column 15-16, (2010/02/13)
The present invention relates to methods for improving the pharmacokinetics of certain compounds useful as inhibitors of the HIV protease enzyme by inhibiting the enzyme activity of cytochrome P450. The present invention also relates to compositions compr
Methods of preparing compounds useful as protease inhibitors
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Page/Page column 29, (2010/02/11)
The invention relates to methods of preparing compounds of formula (I), useful as inhibitors of the HIV protease enzyme. The present invention also relates to intermediate compounds useful in the preparation of compounds of formula (I).
COMPOSITIONS COMPRISING AN HIV PROTEASE INHIBITOR
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Page/Page column 56-57, (2010/02/12)
The present invention relates to pharmaceutical compositions comprising amorphous (4R)-N-allyl-3-{(2S,3S)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylbutanoyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxamide, or a pharmaceutically acceptable salt o
Therapeutic combinations
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Page/Page column 14-15, (2010/02/13)
The present invention relates to methods for treating an HIV infection a mammal by administering to the mammal a therapeutically effective amount of a combination of compounds. The present invention also relates to compositions comprising certain compound
HIV protease inhibitors, compositions containing the same, their pharmaceutical uses, material for their synthesis
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, (2008/06/13)
Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.
HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
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, (2008/06/13)
Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.
