478487-96-6

Upstream product

• 783322-62-3 1-O-methanesulfonyl-2-O-methyl-3,4-O-acetyl-6-O-(4-toluoyl)-D-psicofuranose 
• 783322-61-2 2-O-methyl-3,4-O-isopropylidene-6-O-(4-toluoyl)-D-psicofuranose 
• 344905-99-3 6-O-(4-toluoyl)-1,2:3,4-di-O-isopropylidene-β-D-psicofuranose 
• 4005-49-6 N-benzoyladenine 
• 478487-98-8 4-Methyl-benzoic acid (2R,3R,4R)-3,4-diacetoxy-5-bromo-5-methanesulfonyloxymethyl-tetrahydro-furan-2-ylmethyl ester 

Downstream Products

• 783322-66-7 9-[1',3'-O-anhydro-6'-O-(4,4'-dimethoxytrityl)-β-D-psicofuranosyl]-N⁶-(phenoxyacetyl)adenine 
• 783322-65-6 9-[1',3'-O-anhydro-4',6'-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-psicofuranosyl]-N⁶-(phenoxyacetyl)-adenine 

Relevant academic research and scientific papers

Synthesis, physicochemical and biochemical studies of 1′,2′- oxetane constrained adenosine and guanosine modified oligonucleotides, and their comparison with those of the corresponding cytidine and thymidine analogues

We have earlier reported the synthesis and antisense properties of the conformationally constrained oxetane-C and -T containing oligonucleotides, which have shown effective down-regulation of the proto-oncogene c-myb mRNA in the K562 human leukemia cells.