783322-66-7

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 783322-65-6 9-[1',3'-O-anhydro-4',6'-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-psicofuranosyl]-N⁶-(phenoxyacetyl)-adenine 
• 783322-63-4 9-[1'-O-methanesulfonyl-4',6'-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-psicofuranosyl]adenine 
• 783322-64-5 9-[1',3'-O-anhydro-4',6'-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-psicofuranosyl]adenine 
• 783322-62-3 1-O-methanesulfonyl-2-O-methyl-3,4-O-acetyl-6-O-(4-toluoyl)-D-psicofuranose 
• 783322-61-2 2-O-methyl-3,4-O-isopropylidene-6-O-(4-toluoyl)-D-psicofuranose 
• 478487-96-6 9-[1'-O-methanesulfonyl-3',4'-O-acetyl-6'-O-(4-toluoyl)-β-D-psicofuranosyl]-N⁶-benzoyladenine 
• 478487-98-8 4-Methyl-benzoic acid (2R,3R,4R)-3,4-diacetoxy-5-bromo-5-methanesulfonyloxymethyl-tetrahydro-furan-2-ylmethyl ester 
• 344905-99-3 6-O-(4-toluoyl)-1,2:3,4-di-O-isopropylidene-β-D-psicofuranose 
• 4005-49-6 N-benzoyladenine 
• 478487-97-7 9-(1',3'-O-anhydro-β-D-psicofuranosyl)adenine 
• 873957-60-9 9-[6'-O-benzyl-1'-O-(4-toluenosulfonyl)-β-D-psicofuranosyl]adenine 
• 873957-61-0 9-[6'-O-benzyl-1',3'-O-anhydro-β-D-psicofuranosyl]adenine 

Relevant academic research and scientific papers

Facile preparation of the oxetane-nucleosides

Efficient and practical large scale synthesis of suitably protected 1′, 2′-oxetane locked purine and pyrimidine nucleosides for incorporation in oligo-DNA or -RNA by solid-phase synthesis is reported. A high regio and stereoselectivity with preferential f

Synthesis, physicochemical and biochemical studies of 1′,2′- oxetane constrained adenosine and guanosine modified oligonucleotides, and their comparison with those of the corresponding cytidine and thymidine analogues

We have earlier reported the synthesis and antisense properties of the conformationally constrained oxetane-C and -T containing oligonucleotides, which have shown effective down-regulation of the proto-oncogene c-myb mRNA in the K562 human leukemia cells.