478487-98-8

Upstream product

• 478487-93-3 methyl 1-O-mesyl-5-O-toluoyl-β-D-psicofuranoside 
• 478487-92-2 4-Methyl-benzoic acid (3aR,4R,6R,6aR)-6-methanesulfonyloxymethyl-6-methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 
• 478487-91-1 4-Methyl-benzoic acid (3aR,4R,6R,6aR)-6-hydroxymethyl-6-methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 
• 874-60-2 4-methyl-benzoyl chloride 
• 34626-95-4 1,2:3,4-di-O-isopropylidene-β-D-psicofuranose 
• 783322-61-2 2-O-methyl-3,4-O-isopropylidene-6-O-(4-toluoyl)-D-psicofuranose 
• 344905-99-3 6-O-(4-toluoyl)-1,2:3,4-di-O-isopropylidene-β-D-psicofuranose 
• 783322-62-3 1-O-methanesulfonyl-2-O-methyl-3,4-O-acetyl-6-O-(4-toluoyl)-D-psicofuranose 
• 478487-95-5 4-Methyl-benzoic acid (2R,3R,4R)-3,4,5-triacetoxy-5-methanesulfonyloxymethyl-tetrahydro-furan-2-ylmethyl ester 
• 478487-94-4 4-Methyl-benzoic acid (2R,3R,4R,5R)-3,4-diacetoxy-5-methanesulfonyloxymethyl-5-methoxy-tetrahydro-furan-2-ylmethyl ester 

Downstream Products

• 783322-66-7 9-[1',3'-O-anhydro-6'-O-(4,4'-dimethoxytrityl)-β-D-psicofuranosyl]-N⁶-(phenoxyacetyl)adenine 
• 783322-72-5 9-[1',3'-O-anhydro-6'-O-(4,4'-dimethoxytrityl)-β-D-psicofuranosyl]-N²-(N,N-(dimethylamino)methylene)guanine 
• 783322-68-9 9-[1'-O-methanesulfonyl-3',4'-O-acetyl-6'-O-(4-toluoyl)-β-D-psicofuranosyl]-N²-acetylguanine 
• 783322-65-6 9-[1',3'-O-anhydro-4',6'-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-psicofuranosyl]-N⁶-(phenoxyacetyl)-adenine 
• 478487-96-6 9-[1'-O-methanesulfonyl-3',4'-O-acetyl-6'-O-(4-toluoyl)-β-D-psicofuranosyl]-N⁶-benzoyladenine 

Relevant academic research and scientific papers

Synthesis and anti-HCV activity of 1-(1′,3′-O-anhydro-3′-C-methyl-β-d-psicofuranosyl)uracil

Synthesis of a novel 1′,2′-oxetane-uridine bearing a 2′-C-methyl substituent, [1-(1′,3′-O-anhydro-3′-C-methyl-β-d-psicofuranosyl)uracil], is described. Key to its construction was the use of 6-O-(p-toluoyl)-1,2:3,4-di-O-isopropylidene-3-C-methyl-d-psicofu

Synthesis, physicochemical and biochemical studies of 1′,2′- oxetane constrained adenosine and guanosine modified oligonucleotides, and their comparison with those of the corresponding cytidine and thymidine analogues

We have earlier reported the synthesis and antisense properties of the conformationally constrained oxetane-C and -T containing oligonucleotides, which have shown effective down-regulation of the proto-oncogene c-myb mRNA in the K562 human leukemia cells.

Synthesis of anhydro psicofuranosyl nucleosides

Methyl 1-O-mesyl-5-O-toluoyl-β-D-psicofuranoside (5) was synthesised from the known 1,3;4,5-di-O-isopropylidene-β-D-psicofuranose (1) as a key carbohydrate precursor for the preparation of anhydro psicofuranosyl nucleosides. Transformation of 5 into aceta