4789-11-1

Usage

Uses

Used in Pharmaceutical Industry:
1-P-TOLYL-PIPERIDIN-2-ONE is used as a muscle relaxant and antispasmodic agent for treating muscle spasms, tension, and pain associated with musculoskeletal conditions. Its mechanism of action involves the modulation of neurotransmitter receptor activity in the central nervous system, providing relief from discomfort and improving mobility.
Used in Neurological Research:
1-P-TOLYL-PIPERIDIN-2-ONE is used as a subject of research for potential applications in neurology and neurodegenerative diseases due to its demonstrated neuroprotective and neuroregenerative effects. These properties suggest that PTT could play a role in the development of treatments for conditions affecting the nervous system.
Used in Chronic Pain Management:
1-P-TOLYL-PIPERIDIN-2-ONE is used in the treatment of chronic low back pain, offering a well-tolerated option with minimal side effects for patients suffering from persistent musculoskeletal pain. Its efficacy in managing chronic pain conditions makes it a valuable asset in pain management therapies.

Upstream product

• 110224-25-4 5-chlorovaleric acid p-toluidide 
• 111-29-5 1 ,5-pentanediol 
• 106-49-0 p-toluidine 
• 675-20-7 piperidin-2-one 
• 624-31-7 4-tolyl iodide 
• 110-89-4 piperidine 
• 106-43-4 para-chlorotoluene 
• 31053-03-9 N-(4-methylphenyl)piperidine 
• 2101-86-2 p-methylazidobenzene 
• 201230-82-2 carbon monoxide 

Relevant academic research and scientific papers

Ruthenium-catalyzed synthesis of: N -substituted lactams by acceptorless dehydrogenative coupling of diols with primary amines

Herein, we report the first example of synthesis of N-substituted lactams via an acceptorless dehydrogenative coupling of diols with primary amines in one step, which was enabled by combining Ru3(CO)12 with a hybrid N-heterocyclic carbene-phosphine-phosphine ligand as the catalyst.

Ruthenium-Pincer-Catalyzed Hydrogenation of Lactams to Amino Alcohols

By using the commercially available ruthenium pincer complex (Ru-MACHO-BH) as a catalyst, the challenging direct hydrogenation of lactams and analogues has been successfully accomplished to deliver corresponding value-added amino alcohols in good-to-excellent yields under mild reaction conditions. Remarkably, in addition to N-protected lactams, unprotected ones could also be readily reduced in the presence of a catalytic amount of weak base or even under neutral reaction conditions, which further highlights the broad substrate scope and the protocol efficiency.

Transition-Metal-Free Amine Oxidation: A Chemoselective Strategy for the Late-Stage Formation of Lactams

A metal-free strategy for the formation of lactams via selective oxidation of cyclic secondary and tertiary amines is described. Molecular iodine facilitates both chemoselective and regioselective oxidation of C-H bonds directly adjacent to a cyclic amine. The mild conditions, functional group tolerance, and substrate scope are demonstrated using a suite of diverse small molecule cyclic amines, including clinically approved drug scaffolds.

Reaction of β-, γ-, and δ-chloroalkanamides with potassium tert-butoxide in tetrahydrofuran: Elimination, and lactamization

γ- and δ-Chloroalkanamides were found to undergo lactamization readily when treated with potassium tert-butoxide in tetrahydrofuran. Raising the reaction temperature may encourage SN2 displacement reaction. On the other hand β-chloroalkanamides only undergo elimination, followed by dimerization and trimerization of the acrylamide initially formed.