4789-11-1

Basic information

• Product Name: 1-P-TOLYL-PIPERIDIN-2-ONE
• Synonyms: 1-P-TOLYL-PIPERIDIN-2-ONE
• CAS NO: 4789-11-1
• Molecular Formula: C₁₂H₁₅NO
• Molecular Weight: 189.2536
• Mol File: 4789-11-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 87 °C
• Boiling Point: 397.1±21.0 °C(Predicted)
• Appearance: /
• Density: 1.084±0.06 g/cm3(Predicted)
• PKA: 1.06±0.20(Predicted)
• CAS DataBase Reference: 1-P-TOLYL-PIPERIDIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-P-TOLYL-PIPERIDIN-2-ONE(4789-11-1)
• EPA Substance Registry System: 1-P-TOLYL-PIPERIDIN-2-ONE(4789-11-1)

Safety Data

• Hazardous Substances Data: 4789-11-1(Hazardous Substances Data)

Usage

General Description

1-P-Tolyl-piperidin-2-one, also known as PTT or Tolperisone, is a chemical compound with the molecular formula C13H17NO. It is a piperidinone derivative that is used as a muscle relaxant and antispasmodic agent. PTT acts by modulating the activity of the central nervous system, specifically by binding to and blocking certain neurotransmitter receptors. It is commonly used to treat muscle spasms, tension, and pain associated with musculoskeletal conditions. PTT has also been found to have potential neuroprotective and neuroregenerative effects, making it a subject of research for potential applications in neurology and neurodegenerative diseases. Additionally, PTT has shown promising results in the treatment of chronic low back pain and is well-tolerated with minimal side effects, making it a valuable option for patients suffering from musculoskeletal disorders.

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Relevant articles and documents

Reactions of organoazides with nickel alkyls. Syntheses and reactions of nickel(II) amido complexes

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Ruthenium-Pincer-Catalyzed Hydrogenation of Lactams to Amino Alcohols

By using the commercially available ruthenium pincer complex (Ru-MACHO-BH) as a catalyst, the challenging direct hydrogenation of lactams and analogues has been successfully accomplished to deliver corresponding value-added amino alcohols in good-to-excellent yields under mild reaction conditions. Remarkably, in addition to N-protected lactams, unprotected ones could also be readily reduced in the presence of a catalytic amount of weak base or even under neutral reaction conditions, which further highlights the broad substrate scope and the protocol efficiency.

Reaction of β-, γ-, and δ-chloroalkanamides with potassium tert-butoxide in tetrahydrofuran: Elimination, and lactamization

γ- and δ-Chloroalkanamides were found to undergo lactamization readily when treated with potassium tert-butoxide in tetrahydrofuran. Raising the reaction temperature may encourage SN2 displacement reaction. On the other hand β-chloroalkanamides only undergo elimination, followed by dimerization and trimerization of the acrylamide initially formed.