478929-28-1

Upstream product

• 69838-98-8 1-(4-methoxybenzoyl)pyrrolidine 
• 123-75-1 pyrrolidine 
• 99-96-7 4-hydroxy-benzoic acid 
• 27914-73-4 4-acetoxybenzoyl chloride 
• 2345-34-8 4-acetyloxy-benzoic acid 
• 100-07-2 4-methoxy-benzoyl chloride 

Downstream Products

• 635719-33-4 7-(2-Butynyl)-1-methyl-8-(piperazin-1-yl)-2-[4-(pyrrolidine-1-carbonyl)phenoxy]-1,7-dihydropurin-6-one trifluoroacetate 
• 913381-01-8 (4-(4-bromobutoxy)phenyl)(pyrrolidin-1-yl)methanone 
• 913381-02-9 (4-(6-bromohexyloxy)phenyl)(pyrrolidin-1-yl)methanone 
• 1158976-13-6 C₁₅H₁₉FN₂O₂*ClH 
• 1160829-26-4 C₂₄H₃₀BNO₄ 

Relevant academic research and scientific papers

New histamine H3-receptor ligands of the proxifan series: Imoproxifan and other selective antagonists with high oral in vivo potency

Histamine H3-receptor antagonists of the proxifan series are described. The novel compounds possess a 4-(3-(phenoxy)propyl)-1H-imidazole structure and various functional groups, e.g., an oxime moiety, on the phenyl ring. Synthesis of the novel

Decarbonylative Diaryl Ether Synthesis by Pd and Ni Catalysis

Because diaryl ethers are present as an important motif in pharmaceuticals and natural products, extensive studies for the development of novel methods have been conducted. A conventional method for the construction of the diaryl ether moiety is the intermolecular cross-coupling reaction of aryl halides and phenols with a copper or palladium catalyst. We developed a catalytic decarbonylative etherification of aromatic esters using a palladium or nickel catalyst with our enabling diphosphine ligand to give the corresponding diaryl ethers. The present reaction can be conducted on gram scale in excellent yield. This reaction not only functions in an intramolecular setting but also allows for a cross-etherification using other phenols.

Aurora isoform selectivity: Design and synthesis of imidazo[4,5- B ]pyridine derivatives as highly selective inhibitors of aurora-A kinase in cells

Aurora-A differs from Aurora-B/C at three positions in the ATP-binding pocket (L215, T217, and R220). Exploiting these differences, crystal structures of ligand-Aurora protein interactions formed the basis of a design principle for imidazo[4,5-b]pyridine-

Design, synthesis and evaluation of galanthamine derivatives as acetylcholinesterase inhibitors

A new series of galanthamine derivatives have been designed, synthesized and evaluated as acetylcholinesterase inhibitors. All of the new compounds prepared showed high AChE inhibitory activities, with compound 3e that has an N-hexyl-benzyl piperidine substituent on the nitrogen atom reaching the best inhibitory activity for AChE (IC50 = 5.62 nM). The docking study performed with AutoDock demonstrated that 3e was nicely accommodated by AChE.