479630-02-9

Usage

Molecular structure

The compound has a 4-piperidinepropanoic acid core structure, with a beta-keto group, a BOC protecting group, and a methyl ester group.

Functional groups

The compound contains an ester group, a ketone group, and a methyl group.

Protecting group

The BOC group serves as a protecting group for the beta-keto functionality, allowing for selective reactions.

Use in synthesis

The compound is commonly used as a building block in the synthesis of various pharmaceuticals and biologically active compounds.

Application in pharmaceutical industry

It is often used in the development of potential drug candidates or as a precursor for the synthesis of complex molecules.

Chemical properties

The specific chemical properties of the compound are not provided in the material, but its use as a building block and a precursor in synthesis suggests that it has reactive functional groups that can undergo various chemical reactions.

Upstream product

• 17640-15-2 methyl cyanoformate 
• 206989-61-9 4-acetyl-1-(t-butoxycarbonyl)piperidine 
• 2033-24-1 cycl-isopropylidene malonate 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 67-56-1 methanol 
• 1336874-02-2 tert‐butyl 4‐(2,2‐dimethyl‐4,6‐dioxo‐1,3‐dioxane‐5‐carbonyl)piperidine‐1‐carboxylate 

Downstream Products

• 550377-06-5 4-(5-oxo-4,5-dihydro-1H-pyrazol-3-yl)piperidine-1-carboxylic acid tert-butyl ester 
• 766545-84-0 4-[1-tert-butoxycarbonyl-5-(2,3-dichloro-phenyl)-1H-pyrazol-3-yl]-piperidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis and characterization of novel methyl (3)5-(n-boc-piperidinyl)-1h-pyrazole-4-carboxylates

Series of methyl 3-and 5-(N-Boc-piperidinyl)-1H-pyrazole-4-carboxylates were developed and regioselectively synthesized as novel heterocyclic amino acids in their N-Boc protected ester form for achiral and chiral building blocks. In the first stage of the

Regioselective synthesis of methyl 5-(N-Boc-cycloaminyl)-1,2- oxazole-4-carboxylates as new amino acid-like building blocks

A convenient and efficient synthesis of novel achiral and chiral heterocyclic amino acid-like building blocks was developed. Regioisomeric methyl 5-(N-Boc-cycloaminyl)-1,2-oxazole-4-carboxylates were prepared by the reaction of β-enamino ketoesters (including azetidine, pyrrolidine or piperidine enamines) with hydroxylamine hydrochloride. Unambiguous structural assignments were based on chiral HPLC analysis, 1H, 13C, and 15N NMR spectroscopy, HRMS, and single-crystal X-ray diffraction data.

DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES

The application describes dihydropyrimidine derivatives which are useful in the treatment or prevention of HBV infection or of HBV-induced diseases, more particularly of HBV chronic infection or of diseases induced by HBV chronic infection, as well as pharmaceutical or medical applications thereof.

HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS

Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.

COMPOUNDS AND COMPOSITIONS AS TGR5 AGONISTS

The invention provides compounds of formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with TGR5.

Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: An approach for inhibiting protein-protein interactions

Fragment assembly has shown promise for discovering small-molecule antagonists for difficult targets, including protein-protein interactions. Here, we describe a process for identifying a 60 nM inhibitor of the interleukin-2 (IL-2)/IL-2 receptor (IL-2Rα)