480452-37-7

Basic information

• Product Name: EthanediaMide iMpurity F
• Synonyms: EthanediaMide iMpurity F;N1-(5-chloropyridin-2-yl)-N2-((1S,2R,4S)-2-[(tert-Butoxycarbonyl)Amino ]-4-[(dimethylamino)carbonyl]-cyclohexyl) oxalamide dimethanesulfonate;Edoxaban Impurity 5
• CAS NO: 480452-37-7
• Molecular Formula: C₁₆H₂₂ClN₅O₃
• Molecular Weight: 88.06536
• Mol File: 480452-37-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Density: 1.34±0.1 g/cm3(Predicted)
• PKA: 9.46±0.70(Predicted)
• CAS DataBase Reference: EthanediaMide iMpurity F(CAS DataBase Reference)
• NIST Chemistry Reference: EthanediaMide iMpurity F(480452-37-7)
• EPA Substance Registry System: EthanediaMide iMpurity F(480452-37-7)

Safety Data

• Hazardous Substances Data: 480452-37-7(Hazardous Substances Data)

Upstream product

• 480452-36-6 carbamic acid, N-[(1R,2S,5S)-2-[[2-[(5-chloro-2-pyridinyl)amino]-2-oxoacetyl]amino]-5-[(dimethylamino)carbonyl]cyclohexyl]-1,1-dimethylethyl ester 
• 349125-08-2 ethyl 2-((5-chloropyridin -2-yl)amino)-2-oxoacetate 
• 365998-36-3 (1S,2R,4S)-N₂-(tert-butoxycarbonyl)-4-(N,N-dimethylcarbamoyl)-1,2-cyclohexanediamine 
• 1072-98-6 5-chloro-2-pyridylamine 

Downstream Products

• 480449-70-5 edoxaban 
• 480449-71-6 [14C]-Edoxaban tosylate 

Relevant articles and documents

Preparation method of edoxaban and intermediate thereof

The invention relates to a preparation method of edoxaban and an intermediate thereof. A compound 1, a compound 2 and a compound 5 which are taken as initial raw materials are subjected to an ammonolysis reaction, a deprotection reaction, a carboxylation reaction and a condensation reaction to generate edoxaban. Compared with the prior art, the preparation method is higher in operability and safety during amplified production, and the obtained product is high in yield and purity.

METHOD OF PRODUCING EDOXABAN

PROBLEM TO BE SOLVED: To provide a method of producing edoxaban, which exhibits FXa inhibitory effect and is useful as an agent for preventing and/or treating a thrombotic and/or embolic disease, where the method realizes low cost, high reaction efficiency, reduced time consumption, and high product purity and is suitable for large-scale industrial production. SOLUTION: A method of producing edoxaban (formula 1) includes a method illustrated by the reaction formula in the figure. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT

Preparation method of antithrombotic drug

The invention relates to a preparation method of an antithrombotic drug, belongs to the technical field of medicinal chemistry and in particular relates to a preparation method of a direct coagulationfactor Xa inhibitor, which is shown as the following reaction. Compared with the existing process, the preparation method has the advantages of mild reaction condition in each step, high yield, simplicity and convenience operation, stable process and suitability for large-scale industrial production.