4806-81-9Relevant articles and documents
Iron-Catalyzed Intramolecular Aminations of C(sp3)?H Bonds in Alkylaryl Azides
Alt, Isabel T.,Guttroff, Claudia,Plietker, Bernd
supporting information, p. 10582 - 10586 (2017/08/22)
The nucleophilic iron complex Bu4N[Fe(CO)3(NO)] (TBA[Fe]) catalyzes the direct intramolecular amination of unactivated C(sp3)?H bonds in alkylaryl azides, which results in the formation of substituted indoline and tetrahydroquinoline derivatives.
A General Strategy for the Nickel-Catalyzed C-H Alkylation of Anilines
Ruan, Zhixiong,Lackner, Sebastian,Ackermann, Lutz
supporting information, p. 3153 - 3157 (2016/03/12)
The C-H alkylation of aniline derivatives with both primary and secondary alkyl halides was achieved with a versatile nickel catalyst of a vicinal diamine ligand. Step-economic access to functionalized 2-pyrimidyl anilines, key structural motifs in anticancer drugs, is thus provided. The C-H functionalization proceeded through facile C-H activation and SET-type C-X bond cleavage with the assistance of a monodentate directing group, which could be removed in a traceless fashion.
Structure-activity relationship study of E6 as a novel necroptosis inducer
Mou, Jianfeng,Park, Ann,Cai, Yu,Yuan, Junying,Yuan, Chengye
supporting information, p. 3057 - 3061 (2015/06/22)
Necroptosis inducers represent a promising potential treatment for drug-resistant cancer. We herein describe the structure modification of E6, which was identified recently as a potent and selective necroptosis inducer. The studies described herein demonstrate for the first time that functionalized biphenyl derivatives possess necroptosis inducer activity. Furthermore, these studies have led to the identification of two promising compounds (5h and 5j) that can be used for further optimization studies as well as mechanism of action investigations.
Rh2(II)-catalyzed intramolecular aliphatic C-H bond amination reactions using aryl azides as the N-atom source
Nguyen, Quyen,Sun, Ke,Driver, Tom G.
, p. 7262 - 7265 (2012/06/16)
Rhodium(II) dicarboxylate complexes were discovered to catalyze the intramolecular amination of unactivated primary, secondary, or tertiary aliphatic C-H bonds using aryl azides as the N-atom precursor. While a strong electron-withdrawing group on the nitrogen atom is typically required to achieve this reaction, we found that both electron-rich and electron-poor aryl azides are efficient sources for the metal nitrene reactive intermediate.
HI-catalyzed hydroamination and hydroarylation of alkenes
Marcsekova, Klaudia,Doye, Sven
, p. 145 - 154 (2007/12/27)
Aromatic amines react with alkenes in the presence of catalytic amounts of aqueous HI to give mixtures ef the corresponding hydroamination and hydroarylation products. While the hydroamination reaction is the preferred pathway for aliphatic alkenes, the h
1,2-Di(cyclic)substituted benzene compounds
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Page/Page column 78, (2008/06/13)
In one aspect, the present invention provides compounds having formula (1) or (100), a salt thereof or a hydrate of the foregoing, which compounds exhibit excellent cell adhesion inhibitory action or cell infiltration inhibitory action, and are useful as therapeutic or prophylactic agents for various inflammatory diseases and autoimmune diseases associated with adhesion and infiltration of leukocytes, such as inflammatory bowel disease (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome; rheumatoid arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis. wherein R10 represents optionally substituted cycloalkyl, etc., R20-23 represent hydrogen, alkyl, alkoxy, etc., R30-32 represent hydrogen, alkyl, oxo, etc., and R40 represents optionally substituted alkyl, etc.
Design of arylimine postmetallocene catalytic systems for olefin polymerization: I. Synthesis of substituted 2-cycloalkyl- and 2,6-dicycloalkylanilines
Oleinik,Oleinik,Abdrakhmanov,Ivanchev,Tolstikov
, p. 1423 - 1427 (2007/10/03)
A convenient synthetic approach to substituted 2-cycloalkyl- and 2,6-dicycloalkylanilines, involving catalytic hydrogenation on Raney nickel in methanol of readily available o-cycloalkenylanilines prepared by reaction of cyclic alkyl halides with anilines
A general, regioselective synthesis of 2-alkylanilines
Harmata,Kahraman
, p. 142 - 144 (2007/10/02)
Reduction of selected 2,1-benzothiazines with sodium amalgam leads to the formation of 2-alkylanilines in high yield. Since the benzothiazines are ultimately derived from aniline, the process constitutes a general, regioselective functionalization of aniline not readily achieved by other means.
Hydroalkylation of Aniline with Pd-Al2O3 and NaCl-AlCl3
Kamiyama, Tsutomi,Enomoto, Saburo,Inoue, Masami
, p. 777 - 781 (2007/10/02)
The hydroalkylation of aniline in a palladium-fused salt system was examined under hydrogen pressure.By using 0.5percent Pd-Al2O3 and fused salt (NaCl-AlCl3), N-cyclohexylaniline (4) was formed as the main product at temperatures below 300 deg C; at higher temperatures, the cyclohexyl group rearranged to form nuclear alkylated products, o- and p-cyclohexylaniline, (5) and (6).The yield of 4 was 27.7percent at 280 deg C; those of 5 and 6 were 5.4 and 7.3percent, respectively, at 400 deg C.The reaction mechanism for the hydroalkylation of aniline with this catalytic system is discussed.
