This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.
481-37-8Relevant articles and documents
Augmenting the efficacy of anti-cocaine catalytic antibodies through chimeric hapten design and combinatorial vaccination
Wenthur, Cody J.,Cai, Xiaoqing,Ellis, Beverly A.,Janda, Kim D.
, p. 3666 - 3668 (2017)
Given the need for further improvements in anti-cocaine vaccination strategies, a chimeric hapten (GNET) was developed that combines chemically-stable structural features from steady-state haptens with the hydrolytic functionality present in transition-state mimetic haptens. Additionally, as a further investigation into the generation of an improved bifunctional antibody pool, sequential vaccination with steady-state and transition-state mimetic haptens was undertaken. While GNET induced the formation of catalytically-active antibodies, it did not improve overall behavioral efficacy. In contrast, the resulting pool of antibodies from GNE/GNT co-administration demonstrated intermediate efficacy as compared to antibodies developed from either hapten alone. Overall, improved antibody catalytic efficiency appears necessary to achieve the synergistic benefits of combining cocaine hydrolysis with peripheral sequestration.
Computational Design and Crystal Structure of a Highly Efficient Benzoylecgonine Hydrolase
Chen, Xiabin,Deng, Xingyu,Hou, Shurong,Li, Qiang,Tong, Junsen,Wang, Jiye,Wu, Yanan,Xie, Tian,Yang, Kang,Yao, Jianzhuang,Yao, Weixuan,Zhang, Yun
, p. 21959 - 21965 (2021)
Benzoylecgonine (BZE) is the major toxic metabolite of cocaine and is responsible for the long-term cocaine-induced toxicity owing to its long residence time in humans. BZE is also the main contaminant following cocaine consumption. Here, we identified the bacterial cocaine esterase (CocE) as a BZE-metabolizing enzyme (BZEase), which can degrade BZE into biological inactive metabolites (ecgonine and benzoic acid). CocE was redesigned by a reactant-state-based enzyme design theory. An encouraging mutant denoted as BZEase2, presented a >400-fold improved catalytic efficiency against BZE compared with wild-type (WT) CocE. In vivo, a single dose of BZEase2 (1 mg kg?1, IV) could eliminate nearly all BZE within only two minutes, suggesting the enzyme has the potential for cocaine overdose treatment and BZE elimination in the environment by accelerating BZE clearance. The crystal structure of a designed BZEase was also determined.
-
Halmos et al.
, p. 1699 (1957)
-
BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF
-
Paragraph 00435, (2016/10/31)
Bolaamphiphilic compounds are provided according to formula (I); where HG1, HG2 and L1 are as defined herein. Provided bolaamphiphilic compounds and the pharmaceutical compositions thereof are useful for delivering GDNF or NGF into animal or human brain.