481-40-3

Basic information

• Product Name: naphthalene-1,4,5-triol
• Synonyms: naphthalene-1,4,5-triol;1,4,5-Naphthalenetriol;1,4,5-Trihydroxynaphthalene;5,8-Dihydroxy-1-naphthol;5-Hydroxy-1,4-naphthalenediol
• CAS NO: 481-40-3
• Molecular Formula: C₁₀H₈O₃
• Molecular Weight: 176.16872
• EINECS: 207-568-0
• Mol File: 481-40-3.mol
• Article Data: 10

Chemical Properties

• Melting Point: 168 °C(Solv: ethanol (64-17-5))
• Boiling Point: 341.9°C at 760 mmHg
• Flash Point: 172.6°C
• Appearance: /
• Density: 1.482g/cm³
• Vapor Pressure: 3.95E-05mmHg at 25°C
• Refractive Index: 1.777
• PKA: 6.84±0.40(Predicted)
• CAS DataBase Reference: naphthalene-1,4,5-triol(CAS DataBase Reference)
• NIST Chemistry Reference: naphthalene-1,4,5-triol(481-40-3)
• EPA Substance Registry System: naphthalene-1,4,5-triol(481-40-3)

Safety Data

• Hazardous Substances Data: 481-40-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H8O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,11-13H

Upstream product

• 108-30-5 succinic acid anhydride 
• 108-95-2 phenol 
• 83-56-7 1,5-dihydroxynaphthalene 
• 6312-53-4 juglone 
• 481-39-0 5-hydroxynaphtho-1,4-quinone 

Downstream Products

• 481-39-0 5-hydroxynaphtho-1,4-quinone 
• 120-80-9 benzene-1,2-diol 
• 99-06-9 3-Carboxyphenol 
• 69-72-7 salicylic acid 
• 108-95-2 phenol 
• 39015-63-9 1,4,8-trihydroxynaphthalene-1-O-β-D-glucopyranoside 
• 481-42-5 5-hydroxy-2-methyl-1,4-naphthoquinone 
• 22266-99-5 2-methyl-5-methoxy-1,4-naphthoquinone 
• 51114-98-8 isosclerone 
• 86309-84-4 methyl 2-(4,5-isopropylidenedioxy-1-naphthyloxy)-4-phenylselenobutanoate 
• 4923-61-9 5-methoxynaphthoquinone 
• 860776-15-4 1-hydroxy-4,5-naphthylene phenylboronate 

Relevant articles and documents

Naphthalene diols: a new class of antioxidants intramolecular hydrogen bonding in catechols, naphthalene diols, and their aryloxyl radicals.

1,8-Naphthalenediol, 5, and its 4-methoxy derivative, 6, were found to be potent H-atom transfer (HAT) compounds on the basis of their rate constants for H-atom transfer to the 2,2-di(4-t-octylphenyl)-1-picrylhydrazyl radical (DOPPH*), k(ArOH/DOPPH)*, or as antioxidants during inhibited styrene autoxidation, k(ArOH/ROO)*, initiated with AIBN. The rate constants showed that 5 and 6 are more active HAT compounds than the ortho-diols, catechol, 1, 2,3-naphthalenediol, 2, and 3,5-di-tert-butylcatechol, 3. Compound 6 has almost twice the antioxidant activity, k(ArOH/ROO)* = 6.0 x 10(6) M(-)(1) s(-1), of that of the vitamin E model compound, 2,2,5,7,8-pentamethyl-6-chromanol, 4. Calculations of the O-H bond dissociation enthalpies compared to those of phenols, (deltaBDEs), of 1-6 predict a HAT order of reactivity of 2 alpha(ROO)* = 0.32, gave the expected order, since the ROO* reaction is more exothermic than the DOPPH* reaction. Compound 6 is sufficiently reactive to react directly with oxygen, and it lies off the log k(ArOH/ROO)* versus deltaBDE plot.

Highly Efficient Synthesis and Structure–Activity Relationships of a Small Library of Substituted 1,4-Naphthoquinones

A platform of highly efficient synthetic methodologies has been established to access a focused library of substituted 1,4-naphthoquinones derivatives functionalized with a diversity of amino/hydroxy/alkyl groups. Furthermore, the structure–activity relationship deduced from antiproliferative activities and toxicities of this 1,4-naphthoquinone library and intracellular reactive oxygen species (ROS) level detections might warrant future potential of plumbagin (2) and compound 13 as promising basic structures to develop novel anti-cancer agents.

New naphthoquinone derivatives against glioma cells

This work was aimed to the development of a set of new naphtoquinone derivatives that can act against glioma. The compounds were tested in order to find out their ability to inhibit the growth of glioma cells, and the results of these assays were correlated with electrochemical analysis and NMR-based reoxidation kinetic studies, suggesting that a redox mechanism underlies and may explain the observed biological behavior. In addition to a full description of the synthetic pathways, electrochemistry, NMR and single crystal X-ray diffraction data are provided.