481-59-4

Upstream product

• 67-56-1 methanol 
• 6273-79-6 Pulvinic acid lacton 
• 186581-53-3 diazomethane 
• 93796-43-1 2'-methoxypulvinic acid 
• 114590-96-4 pulvinic acid 
• 27798-60-3 methyl 2-(2-methoxyphenyl)acetate 
• 866556-32-3 4-methoxy-2-(2-methoxy-phenyl)-3-oxo-butyric acid methyl ester 
• 6200-02-8 (3-methoxy-5-oxo-4-phenyl-5H-furan-2-ylidene)-(2-methoxy-phenyl)-acetic acid methyl ester 
• 866556-33-4 (Z)-4-Methoxy-2-(2-methoxy-phenyl)-3-trimethylsilanyloxy-but-2-enoic acid methyl ester 
• 866556-34-5 1-Methoxy-2-{(Z)-3-methoxy-1-[1-methoxy-1-trimethylsilanyloxy-meth-(Z)-ylidene]-2-trimethylsilanyloxy-allyl}-benzene 

Relevant academic research and scientific papers

Synthesis of leprapinic acid, calycine and analogues by sequential "[3+2] cyclization/suzuki/lactonization" reactions

Calycine and analogues were prepared on the basis of Suzuki cross-coupling reactions of γ-alkylidene-α-hydroxybutenolides - readily available by cyclization of 1,3-dicarbonyl dianions or 1,3-bis(silyl enol ether)s with oxalyl derivatives - and subsequent boron tribromide-mediated lactonization. Leprapinic acid was prepared by chemoselective boron tribromide-mediated deprotection of permethylated leprapinic acid. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.

Dioxolanones as Synthetic Intermediates. Part 3. Biomimetic Synthesis of Pulvinic Acids

The reaction of the phosphorane (16) with methyl arylglyoxylates gives 5-(α-methoxycarbonylarylidene)-2,2-pentamethylene-1,3-dioxolan-4-ones which have been treated with the lithium enolates of t-butyl phenylacetic esters to provide a biomimetic synthesis of pulvinic acids.By this method pulvinic acid (2), vulpinic acid (1), and the unsymmetrically substituted compounds, leprapinic acid (3), and xerocomic acid (4) have been prepared; the last named was obtained via an intermediate (28) in which the phenolic groups were protected as benzyl ethers.

ONE POT ONE STEP PHOTOCONVERSION OF PULVINIC ACID DILASCTONE TO p-METHOXYVULPINIC ACID

The utility of singlet oxygen-methanol as a reagent for nuclear methoxylation of complex organic natural products is illustrated by a one pot one step photoconversion of pulvinic acid dilactone to p-methoxyvulpinic acid.The study is important from biogenetic considerations.

Novel Photochemical Conversion of Pulvinic Acid to Leprapinic acid

Pulvinic acid, an important Lichen acid from the lower variety of lichens has been converted to leprapinic acid in good yields.The conversion has a significance in the biogenesis of lichen acids.