481054-46-0Relevant academic research and scientific papers
An efficient synthesis of taxotere side chain
Devi, Joymati,Saikia, Partha Pratim,Barua, Nabin C.
, p. 616 - 618 (2009)
An efficient synthesis of taxotere side chain has been achieved using Shibasaki's asymmetric Henry reaction as the key step.
Substrate derived peptidic α-ketoamides as inhibitors of the malarial protease PfSUB1
Kher, Samir S.,Penzo, Maria,Fulle, Simone,Finn, Paul W.,Blackman, Michael J.,Jirgensons, Aigars
supporting information, p. 4486 - 4489 (2015/02/19)
Peptidic α-ketoamides have been developed as inhibitors of the malarial protease PfSUB1. The design of inhibitors was based on the best known endogenous PfSUB1 substrate sequence, leading to compounds with low micromolar to submicromolar inhibitory activity. SAR studies were performed indicating the requirement of an aspartate mimicking the P1′ substituent and optimal P1-P4length of the non-prime part. The importance of each of the P1-P4amino acid side chains was investigated, revealing crucial interactions and size limitations.
Studies on synthesis and anti-bacterial activity of novel 4-substituted phenyl-2-oxo-1,3-oxazolidine-5-carboxylates
Madhusudha,Om Reddy,Ramatham,Dubey
, p. 957 - 963 (2007/10/03)
Regioselective opening of glycidic esters with sodium azide gives azido alcohols, which are converted to novel 4-substituted phenyl-2-oxo-1, 3-oxazolidine-5-carboxylates by various methods. These compounds are tested for in vitro anti-bacterial activity against Staphylococcus aureous, E. faecalis and E. faecium.
