4827-19-4

Usage

Uses

Used in Chemical Synthesis:
(E)-1-(3-nitrophenyl)-2-phenyldiazene is used as a reagent in the synthesis of azo dyes and organic pigments for [application reason] its ability to form a wide range of colored compounds that are useful in various industries.
Used in Research and Development:
(E)-1-(3-nitrophenyl)-2-phenyldiazene is used as a research compound for [application reason] its unique structure and reactivity, which allows for the exploration of new chemical reactions and processes.
Used in Pharmaceutical Industry:
(E)-1-(3-nitrophenyl)-2-phenyldiazene is used as an intermediate in the synthesis of certain pharmaceutical compounds for [application reason] its potential to be modified and incorporated into drug molecules.
Used in Dye and Pigment Industry:
(E)-1-(3-nitrophenyl)-2-phenyldiazene is used as a starting material for the production of azo dyes and organic pigments for [application reason] its ability to produce a variety of colors and its compatibility with different substrates.
Safety Precautions:
Due to the explosive nature and sensitivity to heat and shock of (E)-1-(3-nitrophenyl)-2-phenyldiazene, it should be handled with extreme caution in a controlled environment by trained professionals. Proper safety measures, including the use of protective equipment and adherence to safety protocols, should be in place to minimize the risk of accidents.

Upstream product

• 100-65-2 N-Phenylhydroxylamine 
• 36966-84-4 Nitrosophenylamine 
• 99-09-2 3-nitro-aniline 
• 2028-76-4 3-nitrophenyldiazonium chloride 
• 16054-46-9 N'-(3-nitro-phenyl)-N-phenyl-diazene-N-oxide 
• 16054-44-7 N-(3-nitro-phenyl)-N'-phenyl-diazene-N-oxide 
• 99-65-0 meta-dinitrobenzene 
• 64-17-5 ethanol 
• 861363-50-0 N-(3-nitro-phenyl)-N'-phenyl-hydrazine 
• 62-53-3 aniline 
• 586-96-9 Nitrosobenzene 
• 64-19-7 acetic acid 
• 127-09-3 sodium acetate 
• 17122-21-3 1-nitro-3-nitrosobenzene 

Downstream Products

• 2835-59-8 3-(phenyldiazenyl)aniline 

Relevant academic research and scientific papers

Photosensitive and Photoswitchable TRPA1 Agonists Optically Control Pain through Channel Desensitization

Transient receptor potential ankyrin 1 (TRPA1) channel, as a nonselective ligand-gated cation channel robustly in dorsal root ganglion sensory neurons, is implicated in sensing noxious stimuli and nociceptive signaling. However, small-molecule tools targeting TRPA1 lack temporal and spatial resolution, limiting their use for validation of TRPA1 as a therapeutic target for pain. In our previous work, we found that 4,4′-(diazene-1,2-diyl)dianiline (AB1) is a photoswitchable TRPA1 agonist, but the poor water solubility and activity hinder its further development. Here, we report a series of specific and potent azobenzene-derived photoswitchable TRPA1 agonists (series 1 and 2) that enable optical control of the TRPA1 channel. Two representative compounds 1g and 2c can alleviate capsaicin-induced pain in the cheek model of mice through channel desensitization but not in TRPA1 knockout mice. Taken together, our findings demonstrate that photoswitchable TRPA1 agonists can be used as pharmacological tools for study of pain signaling.

Are two azo groups better than one? Investigating the photoresponse of polymer-bisazobenzene complexes

Azobenzene chromophores are an ideal choice for material applications where functionality needs to be activated in a precise remote-controlled fashion. The azobenzene stimuli-response falls into two categories, either based on efficient trans-to-cis photoisomerization and a high cis yield enabling on-off type functions, or relying on a fast trans-cis-trans cycling creating motion in the material system. Herein, we show that using bisazochromophores instead of the more common monoazobenzene derivatives makes a difference in the performance of light-responsive azopolymers, more specifically in photo-orientation and all-optical surface patterning. Our findings point out that polymer-bisazobenzene complexes are an attractive alternative as high-performance photoreponsive materials and that although their properties are highly sensitive to the extent of conjugation in the system, they can be designed into relatively transparent films with high performance for all-optical patterning.