4837-39-2Relevant articles and documents
Synthesis of Symmetrical and Unsymmetrical Thiosulfonates from Disulfides through Electrochemically Induced Disulfide Bond Metathesis and Site-Selective Oxidation
Strehl, Julia,Hilt, Gerhard
supporting information, (2021/10/14)
The anodic generation of symmetrical and unsymmetrical thiosulfonates is presented. First, the oxidation of disulfides yielding symmetrical thiosulfonates was realized. The direct synthesis is performed using a simple quasi-divided cell design, whereby using a supporting electrolyte is unnecessary. Its principle was then expanded to the conversion of unsymmetrical disulfides that were generated in situ through metathesis of two symmetrical disulfides. This enables a direct access to unsymmetrical thiosulfonates without any pre-functionalization or elaborate synthesis of the starting materials for the first time. The reaction scope was investigated by converting differently functionalized aliphatic and aromatic disulfides in moderate to very good yields. Furthermore, a sensitivity assessment for an improved reproducibility and a robustness screen to determine the compatibility of the reaction against functional groups were performed.
Synthesis method of alkyl thiosulfonate compound
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Paragraph 0022-0028; 0050-0112, (2021/07/09)
The invention belongs to the technical field of synthesis of organic compounds, and provides a novel method for preparing an alkyl thiosulfonate compound. According to the method, under the conditions of acid and illumination, direct coupling of a sulfurous acid derivative and alkane is utilized to realize direct synthesis and preparation of the alkyl thiosulfonate compound. According to the method, a direct sulfo-substitution mode of alkane C-H bonds is adopted, reaction functional groups do not need to be configured in advance, conversion to the alkyl thiosulfonate compound is completed in one step, raw materials are cheap and easy to obtain, conditions are mild and green, operation is easy, convenient and safe, and the method has high economic prospects.
Iron(III)-Catalyzed Radical Cross-Coupling of Thiols with Sodium Sulfinates: A Facile Access to Thiosulfonates
Keshari, Twinkle,Kapoorr, Ritu,Yadav, Lal Dhar S.
, p. 1878 - 1882 (2016/07/16)
A convenient and efficient synthesis of symmetrical and asymmetric thiosulfonates from thiols and sodium sulfinates is reported. The protocol involves iron(III)-catalyzed formation of sulfenyl and sulfonyl radicals in situ under aerobic conditions and their subsequent cross-coupling to afford thiosulfonates in 83-96% yield. The utilization of readily available, nontoxic, and inexpensive iron(III) as a catalyst and atmospheric oxygen as an oxidant is within the confines of green and sustainable chemistry.