485395-10-6

Basic information

• Product Name: 5-[4-(ethyloxy)phenyl]-1-phenyl-1,3-dihydro-1',3',4,6(2'H,3H,5H)-tetraoxospiro(-1H-furo[3,4-c]pyrrole-3,2'-[1'H]-indene)
• Synonyms: 5-[4-(ethyloxy)phenyl]-1-phenyl-1,3-dihydro-1',3',4,6(2'H,3H,5H)-tetraoxospiro(-1H-furo[3,4-c]pyrrole-3,2'-[1'H]-indene);5-(4-ethoxyphenyl)-3-phenyl-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetrone
• CAS NO: 485395-10-6
• Molecular Formula: C28H21NO6
• Molecular Weight: 467.46944
• Mol File: 485395-10-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-[4-(ethyloxy)phenyl]-1-phenyl-1,3-dihydro-1',3',4,6(2'H,3H,5H)-tetraoxospiro(-1H-furo[3,4-c]pyrrole-3,2'-[1'H]-indene)(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[4-(ethyloxy)phenyl]-1-phenyl-1,3-dihydro-1',3',4,6(2'H,3H,5H)-tetraoxospiro(-1H-furo[3,4-c]pyrrole-3,2'-[1'H]-indene)(485395-10-6)
• EPA Substance Registry System: 5-[4-(ethyloxy)phenyl]-1-phenyl-1,3-dihydro-1',3',4,6(2'H,3H,5H)-tetraoxospiro(-1H-furo[3,4-c]pyrrole-3,2'-[1'H]-indene)(485395-10-6)

Safety Data

• Hazardous Substances Data: 485395-10-6(Hazardous Substances Data)

Upstream product

• 606-23-5 1H-indene-1,3(2H)-dione 
• 108087-84-9 N-(4-ethoxy-phenyl)-maleamic acid 
• 156-43-4 4-Ethoxyaniline 
• 19077-60-2 1-(4-ethoxyphenyl)-1H-pyrrole-2,5-dione 
• 1807-49-4 2-diazo-indan-1,3-dione 
• 100-52-7 benzaldehyde 

Relevant articles and documents

The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation

Adenylate cyclases (ACs), play a critical role in the conversion of adenosine triphosphate (ATP) into the second messenger cyclic adenosine monophosphate (cAMP). Studies have indicated that adenylyl cyclase type 2 (AC2) is potential drug target for many diseases, however, up to now, there is no AC2-selective agonist reported. In this research, docking-based virtual screening with the combination of cell-based biological assays have been performed for discovering novel potent and selective AC2 agonists. Virtual screening disclosed a novel hit compound 8 as an AC2 agonist with EC50 value of 8.10 μM on recombinant human hAC2 + HEK293 cells. The SAR (structure activity relationship) based on the derivatives of compound 8 was further explored on recombinant AC2 cells and compound 73 was found to be the most active agonist with the EC50 of 90 nM, which is 160-fold more potent than the reported agonist Forskolin and could selectively activate AC2 to inhibit the expression of Interleukin-6. The discovery of a new class of AC2-selective agonists would provide a novel chemical probe to study the physiological function of AC2.